Table 1

Comparisons between MSA and PSP patients with MRI (Student's t test or Pearson χ2)

PSP (n=297)MSA (n=330)All (n=627)p Value
Gender (%F)4245440.49
Mean (SD) age (years) (40–81)67 (7)62 (8)64 (8)<0.001
Mean (SD) age at onset (years) (35–79)64 (7)57 (8)60 (8)<0.001
Mean (SD) disease duration (years) (1–8)3.9 (1.9)4.3 (1.9)4.1 (1.9)0.002
Clinical Global Impression of severity (1–6)
 Mean (SD)3.6 (1.0)3.6 (0.9)3.6 (1.0)0.73
 Borderline/moderately ill (0–2) (%)141012
 Markedly ill (3–4) (%)677370
 Severely/extremely ill (5–6) (%)191718
Modified Hoehn and Yahr (0–5) (%)
 No sign to mild bilateral disease (0–2)1524Embedded Image
 Mild to moderate bilateral disease (3)36290.02
 Severe disability (4)3032
 Wheelchair bound (5)1915
Mean (SD) Schwab and England activities of daily living scale (0–100%)50 (23)55 (24)53 (24)0.02
  • MSA, multiple systems atrophy; PSP, progressive supranuclear palsy.