Table 3

Non-demented ALS patients (n=132) and age-matched, sex-matched and education-matched healthy controls (n=110) stratified using the proposed cognitive domain-based categorisation

Main categoriesPatients n (%)Controls n (%)p ValueSubcategoriesPatients n (%)Controls n (%)p Value
1. Executive dysfunction34 (25.8%)3 (2.7%)<0.0001*multidomain19 (14.4%)0 (0%)<0.0001*
single domain15 (11.4%)3 (2.7%)0.021*
2. NECI23 (17.4%)11 (10.0%)0.142multidomain4 (3.0%)1 (0.9%)0.380
single domain: memory5 (3.8%)1 (0.9%)0.225
language12 (9.1%)4 (3.6%)0.150
visuo-spatial skills2 (1.5%)5 (4.5%)0.250
3. No abnormality detected75 (56.8%)96 (87.3%)<0.0001*
  • * Highlights statistically significant differences between the two groups.

  • ALS, amyotrophic lateral sclerosis; NECI, non-executive cognitive impairment.