Table 3

Regional analysis of cortical thickness (data are expressed as average of left and right hemispheres) in patients with relapsing–remitting multiple sclerosis and relapsing–remitting multiple sclerosis with epilepsy at study entry

Cortical area	RRMS	RRMS/E	p Value
Frontal superior	2.50±0.28 (2.04–3.11)	2.31±0.26 (1.97–3.01)	<0.001
Fronto marginal	2.51±0.45 (2.07–3.10)	2.48±0.21 (2.06–3.02)	0.244
Frontal middle	2.43±0.24 (1.92–2.94)	2.29±0.32 (1.71–2.76)	0.003
Frontal inferior	2.47±0.25 (2.13–2.93)	2.31±0.26 (2.15–2.70)	0.001
Frontal pole	2.44±0.23 (2.11–2.76)	2.22±0.31 (1.63–2.78)	0.005
Frontotemporal	2.53±0.30 (2.02–2.88)	2.43±0.35 (1.96–2.76)	0.043
Temporal superior	2.43±0.28 (2.11–2.76)	2.13±0.33 (1.40–2.70)	<0.001
Temporal middle	2.61±0.46 (2.23–2.95)	2.41±0.42 (2.13–2.81)	0.004
Temporal inferior	2.73±0.42 (2.25–2.89)	2.55±0.43 (2.21–2.68)	0.012
Insular long	1.82±0.35 (1.52–2.14)	1.53±0.34 (1.16–2.38)	<0.001
Occipital inferior	2.14±0.16 (1.87–2.73)	2.07±0.28 (1.58–2.41)	0.324
Occipital middle	2.62±0.23 (2.01–2.97)	2.59±0.26 (1.55–2.62)	0.188
Occipital superior	1.97±0.32 (1.51–2.29)	1.91±0.34 (1.11–2.01)	0.308
Occipitotemporal	2.49±0.18 (2.11–2.81)	2.43±0.27 (1.65–2.46)	0.113
Parietal inferior	2.63±0.28 (1.76–3.00)	2.55±0.27 (1.66–2.78)	0.091
Parietal superior	2.34±0.24 (1.75–2.63)	2.19±0.24 (1.34–2.24)	0.075
Precentral	2.34±0.29 (1.86–2.89)	2.07±0.21 (1.54–2.88)	0.002
Postcentral	2.06±0.21 (1.67–2.43)	1.73±0.29 (1.24–2.19)	0.001
Paracentral	1.96±0.31 (1.51–2.31)	1.83±0.34 (1.24–2.04)	0.097
Subcallosal	3.94±0.41 (3.56–4.33)	3.86±0.40 (3.12–4.05)	0.144
Subcentral	2.66±0.31 (1.92–3.10)	2.56±0.27 (1.92–2.75)	0.078
Occipital pole	1.97±0.34 (1.66–2.23)	1.86±0.32 (1.19–2.03)	0.051
Temporal pole	3.13±0.46 (2.83–3.45)	2.86±0.41 (2.33–3.01)	0.003

Values are mean±SD (range) of cortical thickness for each area (in mm).
RRMS, relapsing–remitting multiple sclerosis; RRMS/E, relapsing–remitting multiple sclerosis with epilepsy.