Study | No of tissue blocks examined | Locations examined in cases | Locations examined in controls | Cerebral amyloid angiopathy detection | Rating of severity of CAA | |
Congo Red stain | Immunohistochemistry | |||||
Masuda 198815 | 6 | BG, HC, I††, L | BG, HC, L | ✓ | × | Bespoke |
Ishihara 199131 | ? | B, C, GM, I, L | B, C, GM, L | ✓ | S | Bespoke |
Ng 199129 | ? | I, ? | HC, L* | ✓ | × | Vinters38 |
Cartier 199932 | ? | B, BG, C, L** | B, BG, C, L** | ✓ | × | Presence/absence |
Mastaglia 200334 | 2–6 | I, L† | I, L† | × | ✓ | Bespoke |
Xu 200330 | ? | I††,? | ? | ✓ | ✓ | Bespoke |
Badhe 200533 | 10–12 | BG, C, HC, L | BG, C, HC, L | ✓ | × | Vinters38 |
Ritter 200514 | 4–5 | BG, C, I, L‡ | BG, C, L‡ | ✓ | × | Vonsattel27 |
Attems 200835 | ? | B, BG, C, L§ | B, BG, C, L§ | × | ✓ | Olichney39 & bespoke |
Guidoux 200836 | 3–5‡‡ | ? | B, BG, C, HC, L¶ | ✓‡‡ | ✓§§ | Presence/absence |
Locations: B, brainstem; BG, basal ganglia; C, cerebellum; GM, central grey matter; HC, hippocampus; I, site of ICH; L, lobar (every lobe unless *parieto-occipital only; †frontal, temporal and parietal only; ‡frontoparietal and occipital only; §frontal, temporal and occipital only; ¶temporal and occipital only; **not specified).
↵†† Presence of CAA specified in vessels at the site of the ICH in CAA positive cases, but unclear whether this was done for all cases.
↵‡‡ Cases but not controls.
↵§§ Controls but not cases.
✓, criterion met; ×, criterion not met; ?, unknown; S, some.
CAA, cerebral amyloid angiopathy; ICH, intracerebral haemorrhage.