Multivariate Cox model of survival to dementia with significant neuroimaging predictors stratified by age, and with addition of cognitive score
| p Value | HR (95% CI) | |
| Significant neuroimaging predictor | ||
| MTA | 0.013 | 1.42 (1.08 to 1.86) |
| Log (WMH/TBV) | 0.060 | 1.81 (0.976 to 3.34) |
| AIREN bilateral thalamic lesions | 0.002 | 8.49 (2.17 to 33.2) |
| Significant neuroimaging + cognitive score predictors | ||
| MTA | 0.049 | 1.32 (1.00 to 1.75) |
| Log (WMH/TBV) | 0.146 | 1.59 (0.851 to 2.96) |
| AIREN bilateral thalamic lesions | 0.040 | 4.11 (1.07 to 15.8) |
| CAMCOG-R | 0.004 | 0.929 (0.884 to 0.976) |
AIREN, relevant imaging change meets imaging criteria as specified in the National Institute of Neurological Disorders and Stroke Association/Internationale pour la Recherche et al'Enseignement en Neurosciences (NINDS/AIREN) criteria; CAMCOG-R, Cambridge Cognitive Assessment-revised; MTA, medial temporal lobe atrophy rating; TBV, total brain volume; WMH, white matter hyperintensity volume.