Table 3

Multivariate Cox model of survival to dementia with significant neuroimaging predictors stratified by age, and with addition of cognitive score

p ValueHR (95% CI)
Significant neuroimaging predictor
 MTA0.0131.42 (1.08 to 1.86)
 Log (WMH/TBV)0.0601.81 (0.976 to 3.34)
 AIREN bilateral thalamic lesions0.0028.49 (2.17 to 33.2)
Significant neuroimaging + cognitive score predictors
 MTA0.0491.32 (1.00 to 1.75)
 Log (WMH/TBV)0.1461.59 (0.851 to 2.96)
 AIREN bilateral thalamic lesions0.0404.11 (1.07 to 15.8)
 CAMCOG-R0.0040.929 (0.884 to 0.976)
  • AIREN, relevant imaging change meets imaging criteria as specified in the National Institute of Neurological Disorders and Stroke Association/Internationale pour la Recherche et al'Enseignement en Neurosciences (NINDS/AIREN) criteria; CAMCOG-R, Cambridge Cognitive Assessment-revised; MTA, medial temporal lobe atrophy rating; TBV, total brain volume; WMH, white matter hyperintensity volume.