Mean percent change in confidence of diagnosis from baseline (per-protocol population)
| Suspected diagnosis* at Visit 1 | n | DaTscan (N=102) | ||||||
| Visit 1 | Visit 2 (4 weeks) | Visit 3 (12 weeks) | Visit 4 (1 year) | |||||
| Observed mean (SD) | Observed mean (SD) | % change mean (SD) | Observed mean (SD) | % change mean (SD) | Observed mean (SD) | % change mean (SD) | ||
| Parkinsonian syndrome | 69 | 72.6 (9.42) | 87.3 (13.21) | 21.7 (22.27) | 88.6 (11.41) | 23.6 (20.34) | 90.1 (10.87) | 26.1 (21.70) |
| Non-parkinsonian syndrome | 22 | 79.1 (9.71) | 90.9 (11.92) | 16.6 (19.73) | 90.7 (12.18) | 16.0 (17.84) | 93.2 (11.19) | 19.7 (20.68) |
| Inconclusive | 11 | 50.0 (0.00) | 80.9 (15.62) | 61.8 (31.25) | 83.2 (19.27) | 66.4 (38.54) | 80.9 (21.19) | 61.8 (42.38) |
| Control (N=113) | ||||||||
| Parkinsonian syndrome | 76 | 72.6 (9.22) | 73.5 (10.11) | 1.4 (8.65) | 75.0 (11.12) | 3.5 (11.15) | 77.2 (11.00) | 7.0 (14.61) |
| Non-parkinsonian syndrome | 24 | 78.1 (9.65) | 75.2 (12.38) | −3.8 (9.65) | 77.3 (10.73) | −1.2 (4.04) | 77.1 (11.12) | −0.9 (12.72) |
| Inconclusive | 13 | 50.8 (2.77) | 53.1 (11.09) | 4.9 (23.04) | 50.0 (0.00) | −1.3 (4.63) | 61.5 (18.19) | 21.8 (37.53) |
| Visit 2 vs Visit 1† | Visit 3 vs Visit 1† | Visit 4 vs Visit 1† | ||||||
| Parkinsonian syndrome | p<0.001 | p<0.001 | p<0.001 | |||||
| Non-parkinsonian syndrome | p<0.001 | p<0.001 | p<0.001 | |||||
Data on changes in confidence of diagnosis was not cumulative.
↵* Patients may have more than one clinical diagnosis.
↵† One-sided t-test comparing percent change from baseline in confidence of diagnosis between treatment groups for each visit.
N, number of patients in each treatment group in the per-protocol population; PS, parkinsonian syndrome.