Subject characteristics (n=106)
| Age at baseline (years) | 79.8 (4.11) |
| Sex (F:M) | 57:49 |
| Deceased during follow-up (n (%)) | 60 (57) |
| Developed dementia during follow-up (n (%)) | 27 (25) |
| CAMCOG-R score | 84.4 (8.53) |
| MMSE score | 26.2 (2.69) |
| GDS score | 3.37 (2.96) |
| WMH (ml) | 2.08 (1.81) |
| MTA | 2.71 (1.75) |
| Total brain volume (ml) | 1009 (82.4) |
| Oxford Stroke Classification (LACS/PACS/TACS/POCS/unknown) | 35/42/5/17/7 |
| Any previous stroke/TIA (n=103) (n (%)) | 30 (29) |
| Previous stroke (residual disability) (n=103) (n (%)) | 15 (15) |
| Hypertension (n=105) (n (%)) | 64 (61) |
| Atrial fibrillation (n=105) (n (%)) | 17 (16) |
| Diabetes mellitus (n=101) (n (%)) | 5 (5) |
| Current smoker (n (%)) | 18 (17) |
| Ischaemic heart disease (n=105) (n (%)) | 36 (34) |
| Cortical lesion 40 mm or larger (n (%)) | 25 (24) |
| AIREN bilateral anterior cerebral artery large infarct (n (%)) | 0 (0) |
| AIREN bilateral large vessel infarct (n (%)) | 3 (3) |
| AIREN large vessel—left infarct (n (%)) | 15 (14) |
| AIREN large vessel—right infarct (n (%)) | 25 (24) |
| AIREN association areas large infarct (n (%)) | 27 (26) |
| AIREN posterior cerebral artery stroke (n (%)) | 11 (10) |
| AIREN bilateral thalamic infarct (n (%)) | 6 (6) |
| AIREN basal ganglia small vessel disease (n (%)) | 65 (61) |
| AIREN periventricular WMH (n (%)) | 43 (41) |
| AIREN frontal WMH (n (%)) | 47 (44) |
| AIREN WMH >25% (n (%)) | 27 (26) |
| AIREN any (n (%)) | 102 (96) |
| Any thalamic infarct (n (%)) | 40 (38) |
Values are mean (SD) or n (%).
AIREN, relevant imaging change meets imaging criteria as specified in the National Institute of Neurological Disorders and Stroke Association/Internationale pour la Recherche et al'Enseignement en Neurosciences (NINDS/AIREN) criteria; CAMCOG-R, Cambridge Cognitive Assessment-revised; GDS, Geriatric Depression 15 point Scale; LACS/PACS/TACS/POCS, lacunar/partial anterior/total anterior/posterior syndrome; MTA, medial temporal lobe atrophy rating; MMSE, Mini-Mental State Examination; TIA, transient ischaemic attack; WMH, white matter hyperintensity volume.