Table 1

Occurrence of amyotrophic lateral sclerosis, Parkinson's disease and multiple sclerosis in people with no previous hospital admission for coronary heart disease compared with the occurrence in people with coronary heart disease

ExposureOutcomeDatasetObservedExpectedRate ratio*95% CIp Value
1. No CHDALSORLS1205192.31.320.97 to 1.820.07
2. CHDALSORLS15365.7
1. No CHDALSORLS27764.41.571.06 to 2.380.02
2. CHDALSORLS24052.6
1. No CHDALSEngland13511267.41.141.05 to 1.220.001
2. CHDALSEngland13131396.6
1. No CHDPDORLS114071349.81.141.03 to 1.250.007
2. CHDPDORLS1622679.2
1. No CHDPDORLS2455465.90.950.84 to 1.090.48
2. CHDPDORLS2520509.1
1. No CHDPDEngland80408299.50.950.93 to 0.98<0.001
2. CHDPDEngland12 53312 273.5
1. No CHDMSORLS1367361.31.190.83 to 1.750.33
2. CHDMSORLS13338.7
1. No CHDMSORLS2127125.31.050.74 to 1.540.76
2. CHDMSORLS24142.7
1. No CHDMSEngland20352061.50.950.88 to 1.040.27
2. CHDMSEngland848821.5
  • Data show observed number of admissions (Obs), expected number of admissions (Exp), rate ratio and 95% CIs on the rate ratio.

  • * The rate ratio is the ratio of the observed to expected cases in the non-CHD cohort to the ratio of the observed to expected cases in the CHD cohort, namely (O1/E1)/(O2/E2).

  • Conditions used in the ‘No CHD’ cohort, with Office of Population, Censuses and Surveys (OPCS) code edition 3 for operations and ICD9 code for diagnosis (with equivalent codes used for other coding editions): appendicectomy (OPCS3 441), tonsillectomy (230), knee arthroplasty (812), hip arthroplasty (810, 811), squint (ICD9 378), otitis externa, otitis media (380–382), varicose veins (454), haemorrhoids (455), upper respiratory tract infections (460–466), deflected septum, nasal polyp (470–471), impacted tooth and other disorders of teeth (520–521), inguinal hernia (550), in growing toenail and other diseases of nail (703), sebaceous cyst (706.2), internal derangement of knee (717), bunion (727.1), selected fractures (810–816, 823–826), dislocations, sprains and strains (830–839, 840–848), superficial injury and contusion (910–919, 920–924).

  • ALS, amyotrophic lateral sclerosis; CHD, coronary heart disease; MS, multiple sclerosis; PD, Parkinson's disease.