Univariate Cox survival model for time to dementia
| p Value | HR (95% CI) | |
| Age (years) | 0.003 | 1.12 (1.04 to 1.21)** |
| Male sex | 0.806 | 0.909 (0.425 to 1.95) |
| MTA | 0.003 | 1.43 (1.13 to 1.80)** |
| Log (WMH/TBV) | 0.001 | 2.42 (1.41 to 4.16)** |
| Total brain volume (ml) | 0.183 | 0.995 (0.989 to 1.00) |
| Cortical lesion 40 mm or larger | 0.551 | 0.724 (0.250 to 2.10) |
| AIREN association areas | 0.695 | 1.19 (0.502 to 2.81) |
| AIREN post-cerebral artery infarct | 0.707 | 0.759 (0.179 to 3.21) |
| AIREN basal ganglia | 0.938 | 1.03 (0.472 to 2.25) |
| AIREN frontal WMH | 0.680 | 1.17 (0.550 to 2.50) |
| AIREN periventricular WMH | 0.013 | 2.65 (1.23 to 5.74)* |
| AIREN bilateral thalamic infarct | <0.001 | 6.47 (2.42 to 17.3)** |
| AIREN large vessel—left | 0.874 | 1.09 (0.376 to 3.16) |
| AIREN large vessel—right | 0.457 | 0.668 (0.231 to 1.93) |
| AIREN bilateral large vessel | 0.524 | 0.047 (0.000 to 580) |
| AIREN WMH >25% | 0.025 | 2.41 (1.11 to 5.19)* |
| AIREN sum of scores | 0.024 | 1.40 (1.05 to 1.87)* |
| Any thalamic infarct | 0.436 | 1.35 (0.633 to 2.89) |
| CAMCOG-R | <0.001 | 0.902 (0.865 to 0.941)** |
| MMSE | <0.001 | 0.716 (0.620 to 0.826)** |
*p<0.05; **p<0.01.
AIREN, relevant imaging change meets imaging criteria as specified in the National Institute of Neurological Disorders and Stroke Association/Internationale pour la Recherche et al'Enseignement en Neurosciences (NINDS/AIREN) criteria; CAMCOG-R, Cambridge Cognitive Assessment-revised; MMSE, Mini-Mental State Examination; MTA, medial temporal lobe atrophy rating; TBV, total brain volume; WMH, white matter hyperintensity volume.