Features | Toronto criteria | Mayo criteria | Cambridge criteria |
Temporal profile and treatment response | |||
Insidious onset | 0 | 1+ | 0 |
Asymmetrical onset | 0 | 0 | 1+ |
Chronic progressive course | 0 | 1+ | 0 |
Insidious onset and chronic progression | 0 | 0 | 1− |
Levodopa-resistant | 0 | 1 | 1 |
Sustained levodopa response | Ex | 0 | 0 |
Motor features | |||
Rigidity | 1 | 0 | 0 |
Focal rigidity | 0 | 1 | 0 |
Asymmetrical rigidity | 1 | 1 | 0 |
Akinetic rigid syndrome | 0 | 0 | 1+ |
Dystonia | 0 | 1 | 1 |
Focal dystonia | 1 | 0 | 0 |
Myoclonus | 0 | 0 | 1 |
Reflex focal myoclonus | 1 | 1 | 0 |
Focal or asymmetrical myoclonus | 0 | 1 | 0 |
Rest tremor | Ex | 0 | 0 |
Cortical sensory motor symptoms | |||
Apraxia | 1 | 0 | 1+ |
Asymmetric/focal apraxia | 0 | 1 | 0 |
Number processing deficit | 0 | 0 | 1 |
Cortical sensory loss | 1 | 1 | 1 |
Alien limb | 1 | 1 | 1 |
Visual or sensory hemineglect | 0 | 1 | 0 |
Cognitive symptoms | |||
Early dementia | Ex | 0 | 0 |
Frontal dysfunction | 0 | 1− | 1+ |
Visuospatial deficit | 0 | 0 | 1 |
Apraxia of speech/nonfluent aphasia | 0 | 1 | 1 |
Exclusion features | |||
Early vertical gaze palsy | Ex | 0 | 0 |
Severe autonomic disturbance | Ex | 0 | 0 |
Imaging of other pathology | Ex | 0 | 0 |
Imaging features | 0 | 1−* | 0 |
No identifiable cause | 0 | 1+ | 0 |
0, not required or not relevant; 1, required; 1+, essential criteria in Mayo criteria and Cambridge criteria. In Cambridge criteria, three out of four essential criteria are needed for diagnosis. 1−, supportive criteria; Ex, exclusion criteria.
↵* Mayo criteria include imaging features as supportive feature.