Characteristics and neuropsychological data of control subjects and patients
| Characteristics | Control group (n=30) | MDD group (n=19) | Early bvFTD (n=17) | Moderate bvFTD (n=20) |
| Sex (M/F) | 13/17 | 11/8 | 11/6 | 12/8 |
| Age (years) | 66.2±9.9 (42–82) | 63.3±8.4 (51–82) | 63.1±9.1 (53–83) | 66.7±8.3 (51–73) |
| Education level | 10.7±3.7 (5–16) | 10.5±4.7 (2–17) | 10.8±3.9 (3–15) | 10.4±4.2 (5–17) |
| Tests (maximal score) | ||||
| MMSE (30) | 29±0.9 (27–30)* † ‡ | 26.7±2.2 (23–30)* § | 27.1±2.3 (21–30)† ¶ | 23.3±3.9 (15–28)‡ § ¶ |
| MDRS (144) | NA | NA | 135±3.2 (131–141)¶ | 119.2±12 (92–131)¶ |
| FAB (18) | 17.1±1 (16–18)* † ‡ | 15.9±1.8 (13–18)* § | 15.5±1.8 (13–18)† ¶ | 12.4±3.5 (2–18)‡ § ¶ |
| WCST category (6) | NA | 4.7±1.4 (2–6)§ | 5±1.8 (2–6)¶ | 3.1±1.9 (0–6)§ ¶ |
| WCST perseveration errors | NA | 3.1±3.6 (0–11) | 4.7±6.3 (0–14) | 5.8±4.9 (0–14) |
| WCST attentional errors | NA | 2.2±1.7 (0–6)** | 0.9±1.5 (0–4)** | 1.8±1.7 (0–5) |
| Morphological fluency | NA | 10.8±4.5 (2–20)§ | 9.1±3.6 (4–15)¶ | 3.9±6.4 (1–30)§ ¶ |
Results are expressed as mean±SD (range).
↵* Significant difference between control subjects and MDD. MMSE: p<0.0001; FAB: p<0.05.
↵† Significant difference between control subjects and early bvFTD. MMSE: p<0.001; FAB: p<0.001.
↵‡ Significant difference between control subjects and moderate bvFTD. MMSE: p<0.00001; FAB: p<0.00001.
↵§ Significant difference between MDD and moderate bvFTD. MMSE: p<0.0001; FAB: p<0.0001; WCST category: p=0.01; fluency: p<0.005.
↵¶ Significant difference between early bvFTD and moderate bvFTD. MMSE: p<0.001; FAB: p<0.005; WCST category: p<0.005; fluency: p=0.005; MDRS: p<0.00001.
↵** Significant difference between MDD and early bvFTD. Attention errors in WCST: p=0.01.
bvFTD, behavioural version of frontotemporal dementia; FAB, Frontal Assessment Battery; MDD, major depressive disorder; MDRS, Mattis Dementia Rating Scale; MMSE, Mini-Mental State Examination; WCST, Wisconsin Card Sorting Task.