Comparison of the phenotype frequencies of HLA-DPB1 alleles among patients with NMO/NMOSD, anti-AQP4 antibody positive NMO/NMOSD or anti-AQP4 antibody negative NMO/NMOSD, and healthy controls
| DPB1*X | NMO/NMOSD (n=16) (n (%)) | Anti-AQP4 Ab (+) (n=77) (n (%)) | Anti-AQP4 Ab (−) (n=39) (n (%)) | HCs (n=367) (n (%)) |
|---|---|---|---|---|
| 0201 | 40 (34.5) | 26 (33.8) | 14 (35.9) | 117 (31.9) |
| 0202 | 13 (11.2) | 9 (11.7) | 4 (10.3) | 19 (5.2) |
| 0301 | 6 (5.2) | 4 (5.2) | 2 (5.1) | 16 (4.4) |
| 0401 | 12 (10.3) | 9 (11.7) | 3 (7.7) | 46 (12.5) |
| 0402 | 15 (12.9) | 8 (10.4) | 7 (18.0) | 64 (17.4) |
| 0501 | 95 (81.9)* | 66 (85.7)** | 29 (74.4) | 240 (65.4) |
| 0601 | 1 (0.9) | 1 (1.3) | 0 (0.0) | 6 (1.6) |
| 0901 | 18 (15.5) | 11 (14.3) | 7 (18.0) | 80 (21.8) |
| 1301 | 1 (0.9) | 0 (0.0) | 1 (2.6) | 19 (5.2) |
| 1401 | 1 (0.9) | 1 (1.3) | 0 (0.0) | 10 (2.7) |
| 1601 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (0.5) |
| 1701 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (0.5) |
| 1901 | 3 (2.6) | 1 (1.3) | 2 (5.1) | 3 (0.8) |
| 2201 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.3) |
| 2501 | 2 (1.7) | 1 (1.3) | 1 (2.6) | 0 (0.0) |
| 4101 | 1 (0.9) | 1 (1.3) | 0 (0.0) | 1 (0.3) |
Compared with HCs: *pcorr=0.0124, OR=2.394 (95% CI 1.424 to 4.023); **pcorr=0.0074, OR=3.175 (95% CI 1.619 to 6.227).
puncorr was corrected by multiplying the value by 16 to calculate pcorr.
Ab, antibody; AQP4, aquaporin 4; HCs, healthy controls; HLA, human leukocyte antigen; NMO, neuromyelitis optica; NMOSD, neuromyelitis optica spectrum disorder.