Table 1

The frequency of c9FTD/ALS and average number of repeats in Japanese population

c9FTD/ALS frequencyAverage number of repeats (mean±SD)
nNumber of c9FTD/ALS (%)All individualsIndividuals with rs3849942 allele AIndividuals without rs3849942 allele Ap Value
Controls1800 (0)3.62±2.44 5.67±2.953.13±2.02<0.001
SALS1100 (0)3.33±2.27 5.68±3.213.07±1.97<0.001
FALS* 582 (3.4)3.96±2.85 5.90±3.913.36±2.13<0.01
  • * We calculated the average number of repeats in FALS exclusive of c9FTD/ALS cases.

  • No significant differences between groups, p=0.225, Kruskal–Wallis test.

  • Comparison between individuals with rs3849942 allele A and individuals without allele A, Mann–Whitney U test.

  • ALS, amyotrophic lateral sclerosis; FALS, familial ALS; FTD, frontotemporal dementia; SALS, sporadic ALS.