Table 3

Pathological analysis of neurodegeneration in frontotemporal lobar degeneration (FTLD) with and without the C9orf72 repeat expansion

		C9orf72 expansion positive FTLD (N=13)	C9orf72 expansion negative FTLD (N=12)	p Value
Mid-frontal cortex	Gliosis	2 (2, 3)	1 (0.25, 2)	0.022
	Neuronal loss	2 (2, 3)	2 (1, 2)	0.005
	TDP-43*	3 (2, 3)	2 (1.25, 3)	0.284
	Ubiquilin†	2 (1, 2)	0 (0, 1)	0.001
Superior to mid-temporal cortex	Gliosis	1 (0.5, 2)	2 (1, 2)	0.335
	Neuronal loss	2 (1, 2.5)	2 (1, 2.75)	0.662
	TDP-43	3 (2, 3)	3 (2.75, 3)	0.575
	Ubiquilin*	2 (1, 2)	1 (0, 1.75)	0.050
Angular cortex	Gliosis	1 (0.5, 1.5)	0.5 (0, 2)	0.688
	Neuronal loss	2 (1, 2)	1 (1, 2)	0.771
	TDP-43	2 (1, 3)	2 (1.25, 3)	0.909
	Ubiquilin*	2 (1, 2)	0 (0, 1.5)	0.002
Cingulate cortex	Gliosis	0 (0, 1.5)	1 (0.25, 1.75)	0.298
	Neuronal loss	1 (1, 2)	1 (1, 2)	0.953
	TDP-43*	2.5 (1.25, 3)	3 (2, 3)	0.328
	Ubiquilin*	1.5 (1, 2)	0 (0, 1)	0.002
Thalamus	Gliosis	1 (0, 1)	0 (0, 0.75)	0.198
	Neuronal loss	1 (0, 1)	0 (0, 0.75)	0.109
	TDP-43	2 (0, 2)	1 (0.25, 2.0)	0.842
	Ubiquilin	0 (0, 0.5)	0 (0, 0)	0.286
Granule layer, cerebellum	Gliosis	0 (0, 0)	0 (0, 0)	1.000
	Neuronal loss	0 (0, 0)	0 (0, 0)	1.000
	TDP-43*	0 (0, 0)	0 (0, 0)	0.317
	Ubiquilin	3 (1.5, 3)	0 (0, 0)	0.001