Background information for mutation carriers whose cognitive profiles are shown in figure 2
| Carrier | Age group, 2002 | Education | Comments |
|---|---|---|---|
| 1 | 2 | 13 | No suspicion of symptoms by subject or family. |
| 2 | 2 | 13 | Discrete behavioural changes noted by family in 2010. Depression in winter 2011–12. Formal evaluation in summer 2012: no clear signs of dementia. |
| 3 | 2 | 15 | Severe behavioural changes. Dementia diagnosed in 2010. |
| 4 | 3 | 11 | No reported symptoms. |
| 5 | 1 | 13 | No reported symptoms in 2010. Dementia diagnosed in 2012. |
| 6 | 3 | 10 | No reported symptoms. |
| 7 | 3 | 14 | Discrete cognitive and behavioural changes. Dementia diagnosed in 2011. |
| 8 | 2 | 13 | General impairment and severe language problems. Behavioural changes. Diagnosed with dementia in 2011. |
| 9 | 4 | 8 | Low premorbid level. Clinically demented. Diagnosed in 2011. |
Age: 1: 41–45, 2: 46–50, 3: 51–55, 4: 56–60. Exact age is not listed to keep data blinded to participants. Education: Years of schooling (7–12)+level of education (1–5).