Cognitive domain/test | Mutation carriers (n=17) | Control group (n=51) | p Value | Cohen's d |
---|---|---|---|---|
Psychomotor speed | −0.11 (0.54) | 0.22 (0.70) | 0.04 | 0.47 |
Symbol Digit Modalities Test | 40.8 (7.6) | 46.1 (12.3) | 0.02 | 0.43 |
Trail Making A | 36.3 (11.8) | 31.9 (12.7) | 0.11 | |
Trail Making B | 86.0 (35.5) | 71.9 (28.3) | 0.05 | 0.50 |
Memory | 0.00 (0.69) | 0.18 (0.74) | 0.20 | |
Logical memory (WMS-R), total recall | 41.4 (12.4) | 47.8 (12.2) | 0.03 | 0.52 |
Rey Complex Figure test, 3 min recall | 20.4 (5.8) | 19.7 (6.5) | 0.34 | |
Visuospatial function | −0.08 (0.65) | 0.26 (0.62) | 0.01 | 0.55 |
Rey Complex Figure test, copy | 34.8 (1.3) | 35.2 (1.2) | 0.14 | |
Clock drawing free hand | 12.7 (1.9) | 13.6 (1.7) | 0.45 | |
Executive functions | −0.39 (0.40) | 0.17 (0.49) | 0.06 | 1.14 |
Working memory | −0.59 (0.75) | 0.25 (0.70) | 0.07 | 1.2 |
Letter number sequencing (WAIS-3) | 9.2 (2.1) | 10.4 (2.2) | 0.03 | 0.55 |
Graded difficulty arithmetic test | 13.1 (5.0) | 14.1 (5.1) | 0.25 | |
Fluency | 0.03 (0.51) | 0.05 (0.64) | 0.44 | |
Verbal fluency, category | 42.8 (9.2) | 41.0 (7.8) | 0.22 | |
Verbal fluency, lexical | 26.1 (7.5) | 24.8 (7.7) | 0.28 | |
Design fluency (a.m.Regard) | 22.4 (5.2) | 26.1 (8.0) | 0.04 | 0.46 |
Other executive measures | ||||
Picture arrangement, WAIS | 18.0 (6.0) | 22.4 (5.8) | 0.01 | 0.76 |
Cognitive estimations, 20 items (errors) | 7.8 (5.5) | 6.8 (5.3) | 0.25 |
Domain scores are reported as z-scores (mean and SD). Single test scores are reported as raw scores (mean and SD).