Comparison of demographic characteristics of POMS and AOMS cohorts
| Characteristic | POMS | AOMS | p Value |
|---|---|---|---|
| Total | 111 | 1825 | n/a |
| Female | 82 (73.9) | 1284 (70.4) | 0.42 |
| Caucasian | 107 (96.4) | 1769 (96.9) | 0.99 |
| Family history of MS | 14 (12.6) | 220 (12.1) | 0.91 |
| Disease-modifying treatment | 38 (34.2) | 441 (24.2) | 0.13 |
| Symptoms at onset | |||
| Monofocal | 85 (76.4) | 1265 (69.3) | 0.95 |
| Polyfocal | 26 (23.4) | 305 (16.7) | |
| Current disease course | |||
| RRMS | 53 (47.8) | 757 (41.5) | 0.003 |
| SPMS | 41 (36.9) | 748 (41.0) | |
| PPMS | 1 (0.9) | 155 (8.5) | |
| Mean age at onset (years) | 15.9 (SD 2.9) | 31.9 (SD 8.1) | <0.001 |
| Mean current age (years) | 37.8 (SD 17.7) | 44.6 (SD 20.4) | <0.001 |
| Mean disease duration (years) | 25.3 (SD 15.8) | 17.2 (12) | <0.001 |
| Median ARR in first 5 years of disease | 0.2 (IQR 0.2–0.6) | 0.4 (IQR 0.2–0.6) | 0.05 |
| Median ARR in first 10 years of disease | 0.2 (IQR 0.1–0.4) | 0.2 (IQR 0.1–0.4) | 0.26 |
Unless otherwise stated, values are number (%).
AOMS, adult-onset multiple sclerosis; ARR, annualised relapse rates; MS, multiple sclerosis; POMS, paediatric-onset multiple sclerosis; PPMS, primary progressive multiple sclerosis; RRMS, relapsing remitting multiple sclerosis; SPMS, secondary progressive multiple sclerosis.