Table 2

Individual cases of neurodevelopmental disorder alongside demographic information

DiagnosisGenderAEDDose (mg daily)Maternal epilepsy typeSeizuresCongenital malformationMaternal agePaternal ageSiblings with ASD*AlcoholNicotine
Autistic spectrum disorders
1Asperger's†MVPA 1000IGE1TCMultiple minor3339NoneYesNo
2Autism†MVPA600F1 PS+SGNone27291sibling (VPA exposed)NoNo
3Autism†MVPA1500F2PS+SGNone2230NoneNoYes
4Pervasive Developmental Disorder†MVPA2500IGE2TCNone2329NoneYesYes
5Autism†FVPA+LTG2000+100F2TCNone2637NoneNoNo
6Asperger's†MLTG500F1PS+SGNone3031NoneNoNo
7Asperger's and ADHDFVGB4000F2TCNone19Not knownNoneNoYes
8Autism†MPHT300F0None35Not knownNoneYesNot known
9Autism†MControlN/AN/AN/ANone32Not knownNoneYesNo
10Asperger's†MControlN/AN/AN/ANone3132NoneNoNo
11Asperger's†FControlN/AN/AN/ANone32311 siblingNoNo
12AutismMControlN/AN/AN/A37NoneNoYes
ADHD
13ADHDMVPA+LTG2000+50IGE01 major27402 Siblings (VPA exposed)NoNo
14ADHD‡FCBZ1200F0None2431NoneNoNo
15ADHDMVPA+LTG1500+25F2TCNone18Not knownNoneYesNo
Dyspraxia
16DyspraxiaMLTG100F2 TCNone22Not knownNoneNoNo
17DyspraxiaMVPA600IGE0None2630NoneNoNo
18DyspraxiaMCBZ+LTG600+50UC2TCIsolated minor24Not knownNoneNoNo
19DyspraxiaMVPA1000UC2TCNone40Not knownNoneNoNo
  • *ASD was the only reported diagnosed disorder in siblings.

  • †Case was included in the preliminary report from this cohort.26

  • ‡Child also has idiopathic generalised epilepsy.

  • ADHD, attention deficit hyperactivity disorder; ASD, autistic spectrum disorders; CBZ, carbamazepine; F, focal; IGE, Idiopathic generalised epilepsy; PHT, phenytoin; PS, partial seizures; TC, tonic clonic seizures; UC, unclassified; VGB, vigabatrin. Alcohol includes intake prior to knowledge of conception. Nicotine—smoking even prior to knowledge of conception.