Table 2

Feasibility of application and validation efforts of subtype classifications from data driven studies

CriterionGraham 19993 Gasparoli 20024 Dujardin 20045 Lewis 20056 Schrag 20067 Post 20088 Reijnders 20099 Van Rooden 201110 Liu 201111
Subtypes reproduced in independent cohort?n/an/an/aYes n/an/aYesYesn/a
Algorithm for classification derived?NoNoYesNo NoNoNoYesNo
Percentage of cohort correctly classified by algorithm in independent cohort?n/an/an/an/an/an/an/a77n/a
Distinguishing clinical/demographic features* NoYesYesYesYesYesYesYesNo
Distinguishing pathological features n/an/an/aYes n/an/an/an/an/a
  • * Were subtypes distinguishable on the basis of clinical or demographic features not included in the derivation of the clusters? (See text for details).

  • Were subtypes distinguishable on the basis of pathological findings?

  • By Selikhova et al 13

  • n/a, not assessed.