Table 3

Moderate to severe side effects breakdown, χ2 analysis (intermittent prednisolone n=191; daily prednisolone n=169)

Side effectsIntermittent, n (%)Daily, n (%)χ2 p value
Temper tantrums54 (28)67 (40)0.02*
Mood swings56 (29)64 (38)0.08
Aggressiveness41 (21)49 (29)0.09
Hyperactivity29 (15)39 (23)0.05*
Emotional liability23 (12)32 (19)0.06
Insomnia8 (4)19 (11)0.01*
Cushingoid features28 (15)56 (33)<0.01*
GI symptoms12 (6)23 (14)0.01*
Increased appetite73 (38)78 (46)0.1
Hypertension10 (5)38 (22)<0.01*
Vertebral fractures8 (4)14 (8)0.1
Long bone fractures13 (7)9 (5)0.5
BMD z-score ≤ −2.5*9 (5)14 (8)0.1
Cataracts2 (1)4 (2)0.3
Hirsutism19 (10)24 (14)0.2
Easy bruising5 (3)7 (4)0.4
  • *BMD z score=lumbar spine.

  • BMD, bone mineral density; GI, gastrointestinal.