CAPIT neuropsychology battery assessments
| Tests | Years | 0–2 years (2–4 years pre-T1) | 2–4 years (0–2 years pre-T1) | 4–6 years (0–2 years post-T1) | 6–8 years (0–2 years post-T1) | 8–10 years (0–2 years post-T1) | 10–12 years (0–2 years post-T1) | Groups | Time | Group×Time |
|---|---|---|---|---|---|---|---|---|---|---|
| Mean±SEM | Mean±SEM | Mean±SEM | Mean±SEM | Mean±SEM | Mean±SEM | F1,15 | F5,68 | F5,68 | ||
| Verbal fluency (letters) | Control (n=12) | 31.8±1.9 | 31.3±2.1 | 30.2±2.1 | 27.7±3.5 | 25.7±3.6 | 23.9±5.5 | 0.93 | 7.42** | 2.95 |
| Transplant (n=5) | 299±5.2 | 32.0±6.3 | 27.8±5.9 | 24.1±5.6 | 26.4±4.1 | 19.5±3.0 | ||||
| Verbal fluency (animals) | Control | 15.3±1.1 | 14.5±1.1 | 14.2±1.3 | 11.9±1.6 | 11.9±2.1 | 11.9±2.4 | 0.01 | 15.93** | 0.82 |
| Transplant | 18.0±0.9 | 16.2±2.8 | 13.1±2.2 | 11.4±2.0 | 10.2±1.2 | 9.0±3.0 | ||||
| Symbol digit | Control | 34.6±3.3 | 30.13.2 | 27.0±3.5 | 22.5±3.3 | 21.7±4.6 | 29.2±6.7 | 0.18 | 40.18** | 0.49 |
| Transplant | 33.6±4.3 | 28.9±4.4 | 24.2±3.6 | 21.4±5.0 | 18.5±3.5 | 17.8±5.9 | ||||
| Stroop (colours) | Control | 55.7±3.0 | 48.8±2.9 | 45.8±2.9 | 38.4±3.5 | 34.0±3.3 | 33.7±5.1 | 0.08 | 38.70** | 0.48 |
| Transplant | 51.8±5.0 | 51.0±6.9 | 44.7±7.3 | 37.1±8.3 | 35.5±9.3 | 33.7±10.7 | ||||
| Stroop (words) | Control | 76.4±4.7 | 67.7±4.9 | 59.8±5.4 | 50.7±5.3 | 47.0±5.7 | 41.3±7.3 | 0.09 | 44.63** | 0.71 |
| Transplant | 70.2±6.8 | 71.9±8.8 | 58.9±7.8 | 44.4±8.9 | 45.7±10.0 | 42.6±10.7 | ||||
| Stroop | Control | 31.1±2.1 | 29.9±2.0 | 26.0±1.8 | 22.2±2.2 | 18.5±2.7 | 17.6±3.4 | 0.09 | 27.44** | 0.54 |
| (interference) | Transplant | 30.2±4.9 | 33.2±6.5 | 27.6±4.4 | 23.9±6.8 | 24.7±7.6 | 19.5±7.0 | |||
| MMSE | Control | 28.1±0.5 | 27.9±0.5 | 27.3±0.6 | 27.3±0.8 | 25.7±1.3 | 25.7±1.3 | 0.02 | 10.98** | 0.57 |
| Transplant | 28.1±0.4 | 27.9±0.7 | 28.0±0.5 | 27.4±0.9 | 25.1±1.2 | 25.5±1.8 | ||||
| Hopkins (test 1) | Control | 5.6±0.4 | 5.7±0.5 | 5.4±0.5 | 4.8±0.5 | 4.7±0.7 | 4.7±0.9 | 0.36 | 6.42** | 0.43 |
| Transplant | 5.8±0.9 | 5.6±0.5 | 4.5±0.4 | 4.4±0.8 | 3.9±0.8 | 3.5±0.5 | ||||
| Hopkins (test 2) | Control | 7.4±0.4 | 7.4±0.6 | 7.1±0.5 | 6.7±0.6 | 6.9±0.7 | 6.5±1.2 | 0.12 | 11.42** | 2.06 |
| Transplant | 8.3±0.9 | 7.6±0.6 | 6.8±1.0 | 5.3±0.8 | 5.7±0.5 | 5.0±1.0 | ||||
| Hopkins (test 3) | Control | 8.3±0.6 | 8.7±0.7 | 7.6±0.8 | 7.0±0.7 | 8.1±0.7 | 6.6±1.7 | 0.00 | 7.98** | 1.97 |
| Transplant | 8.8±0.8 | 8.3±0.8 | 8.1±1.0 | 6.2±1.1 | 6.7±0.4 | 7.0±1.0 | ||||
| Hopkins (delays) | Control | 7.7±0.6 | 7.7±0.8 | 6.4±0.9 | 5.8±1.0 | 6.4±1.0 | 6.3±1.5 | 0.07 | 9.63** | 0.54 |
| Transplant | 8.2±0.9 | 7.9±0.9 | 7.2±1.4 | 6.1±1.3 | 5.2±0.3 | 5.5±1.5 | ||||
| WCST (categories) | Control | 5.3±0.4 | 5.7±0.3 | 5.4±0.3 | 5.4±0.3 | 5.4±0.2 | 5.7±0.3 | 2.86 | 5.12** | 4.52** |
| Transplant | 4.7±0.8 | 4.9±1.0 | 4.6±0.9 | 4.5±0.7 | 4.3±1.1 | 1.5±1.5 | ||||
| WCST (errors) | Control | 6.6±2.1 | 6.2±1.9 | 6.5±1.7 | 7.9±2.2 | 6.1±1.1 | 4.4±2.1 | 2.02 | 4.90** | 3.54* |
| Transplant | 11.9±4.7 | 9.0±5.6 | 10.4±4.5 | 13.5±4.8 | 11.9±4.5 | 25.5±8.5 | ||||
| Trails test (form A) | Control | 61.8±7.1 | 58.6±5.3 | 71.6±9.60 | 85.9±11.6 | 76.9±14.5 | 72.7±17.3 | 1.01 | 13.62** | 0.85 |
| Transplant | 67.5±16.7 | 72.1±13.9 | 88.3±20.3 | 90.2±30.3 | 112.2±20.6 | 110.0±57.0 | ||||
| Trails test (form B) | Control | 118.5±12.2 | 162.7±34.9 | 135.7±16.6 | 135.9±18.5 | 155.7±29.3 | 157.4±54.1 | 0.48 | 10.44** | 0.53 |
| Transplant | 135.4±22.1 | 128.7±15.7 | 227.0±97.1 | 164.2±15.7 | 199.7±62.3 | ** | ||||
| Recognition memory | Control | 10.7±0.4 | 10.7±0.5 | 10.2±0.7 | 10.7±0.4 | 10.1±0.5 | 10.0±0.5 | 0.17 | 0.83 | 0.24 |
| Transplant | 11.3±0.3 | 10.8±0.5 | 10.7±0.5 | 10.0±0.9 | 10.5±0.7 | 10.0±3.0 | ||||
| Digit span (forward) | Control | 7.4±0.3 | 7.5±0.4 | 7.4±0.5 | 6.6±0.3 | 7.1±0.5 | 6.2±0.9 | 0.21 | 9.03** | 0.97 |
| Transplant | 7.5±0.4 | 6.6±0.4 | 6.9±0.9 | 6.8±0.7 | 6.0±1.1 | 5.8±0.8 | ||||
| Digit span (backward) | Control | 5.4±0.4 | 4.8±0.4 | 5.0±0.5 | 4.6±0.5 | 4.7±0.6 | 4.3±0.6 | 0.09 | 6.50** | 0.46 |
| Transplant | 5.5±0.5 | 5.1±0.5 | 5.1±0.6 | 5.3±0.9 | 3.5±0.8 | 4.0±0.0 | ||||
| Rivermead (immediate) | Control | 7.4±0.3 | 7.5±0.4 | 7.4±0.5 | 6.6±0.4 | 7.1±0.5 | 6.2±0.9 | 0.40 | 5.91** | 0.82 |
| Transplant | 7.5±0.4 | 6.6±0.4 | 6.9±0.8 | 6.8±0.7 | 6.0±1.1 | 5.8±0.8 | ||||
| Rivermead (delay) | Control | 5.4±0.4 | 4.8±0.4 | 5.0±0.5 | 4.6±0.5 | 4.7±0.6 | 4.3±0.6 | 0.03 | 9.42** | 1.83 |
| Transplant | 5.5±0.5 | 5.1±0.5 | 5.1±0.6 | 5.3±0.9 | 3.5±0.8 | 4.0±0.0 | ||||
| Conditional associates | Control | 34.1±6.8 | 30.1±6.0 | 33.0±7.2 | 39.3±7.2 | 35.6±9.7 | 26.0±11.1 | 0.01 | 4.63** | 0.85 |
| Transplant | 31.8±8.2 | 25.4±7.4 | 31.7±9.3 | 29.9±11.2 | 38.6±15.1 | 50.5±17.5 |
**p<0.001; *p<0.05 (not significant when correcting for multiple comparisons); Transplant improved (+), or impaired (−) with respect to the reference controls.
For Trails test parts A and B, and conditional associates, a LOWER scores indicates a BETTER performance. For all other tests 0 is worse.
CAPIT, Core assessment program for intracerebral transplantations; MMSE, Mini Mental State Examination; WCST, Wisconsin Card Sorting Test.
Note: all significant results are identified in bold.