Demographic and clinical characteristics of the patients
| Whole group | Relapse onset MS | Minimally impaired relapse onset MS, EDSS baseline=0–3.5 | Moderately impaired relapse onset MS, EDSS baseline=4–6 | CIS | RRMS | SPMS | PPMS | |
|---|---|---|---|---|---|---|---|---|
| No of patients | 261 | 184 | 111 | 55 | 18 | 97 | 69 | 77 |
| Women (n (%)) | 148 (57) | 111 (60) | 69 (59) | 33 (60) | 13 (72) | 62 (64) | 36 (52) | 37 (48) |
| Centre (%) | ||||||||
| Ams | 42 | 45 | 43 | 38 | 17 | 46 | 51 | 35 |
| Bar | 29 | 16 | 4 | 36 | – | 2 | 41 | 58 |
| Bas | 4 | 6 | 11 | – | – | 12 | – | – |
| Gra | 1 | 1 | 1 | 2 | – | 2 | – | – |
| Lon | 2 | – | – | – | – | – | – | 7 |
| Mil | 14 | 21 | 27 | 14 | 83 | 21 | 4 | – |
| Oxf | 2 | 3 | 3 | 4 | – | 3 | 3 | – |
| Sie | 6 | 8 | 11 | 6 | – | 14 | 1 | – |
| Baseline age (year)* | 43 (35–52) | 38 (31–46) | 35 (28–40) | 46 (37–53) | 29 (24–34) | 35 (29–40) | 46 (40–52) | 52 (47–58) |
| Disease type at baseline (%) | – | – | _ | _ | ||||
| CIS | 7 | 10 | 13.5 | – | ||||
| RRMS | 37 | 53 | 73 | 24 | ||||
| SPMS | 26 | 37 | 13.5 | 76 | ||||
| PPMS | 30 | – | – | – | ||||
| DD at baseline* | 8 (4–12) | 6 (3–11) | 4 (1–8) | 11 (7–18) | 0 (0–0) | 5 (2–8) | 11 (8–17) | 10 (6–13) |
| EDSS baseline* | 4 (2–6) | 2.5 (1.5–4.5) | 1.5 (1–2.5) | 5.5 (4.5–6) | 0 (0–1) | 2 (1–3) | 5.5 (4–6) | 5.5 (3.5–6.5) |
| EDSS at 10 years* | 6 (4–7.5) | 5 (2.5–6.5) | 3.5 (1.5–5.5) | 6.5 (6–7.5) | 1.5 (1–3) | 3.5 (2–5.5) | 7 (6–7.5) | 7 (6–8) |
| MSSS baseline* | 5.4 (3.3–7.6) | 4.6 (2.8–6.3) | 2.9 (2.1–4.9) | 6.1 (5–7.6) | 2.8 (2.8–3.8) | 3.3 (2.1–5.4) | 5.8 (4.9–7.2) | 7.5 (5.4–8.5) |
| MSSS at 10 years* | 5.8 (3.3–8.1) | 4.6 (2.3–7.3) | 3 (1.5–5.2) | 6.3 (4.8–8.2) | 1.5 (1.1–3.5) | 3 (1.7–5.1) | 7.4 (5.5–8.2) | 7.5 (5.7–9) |
The columns represent the results for the: whole group, relapse onset MS, minimally impaired group (relapse onset patients with baseline EDSS=0–3.5), moderately impaired group (relapse onset patients with baseline EDSS=4–6), CIS, RRMS, SPMS and PPMS patients at baseline. The CIS, RRMS, SPMS and PPMS groups include all patients regardless of their baseline EDSS value.
*Data reported as median (IQR).
CIS, clinically isolated syndrome; DD, disease duration; DMT, disease modifying treatment; EDSS, Expanded Disability Status Scale; MS, multiple sclerosis; MSSS, Multiple Sclerosis Severity Scale; PPMS, primary progressive MS; RRMS, relapsing–remitting MS; SPMS, secondary progressive MS.