Study types and demographics
| Authors | Year | Duration of study | Operation type | No of patients | Mean age, years (range) | Women (%) | Macroadenomas (%) |
|---|---|---|---|---|---|---|---|
| Jho and Carrau3 | 1997 | 1993–6 | Endoscopic | 44 | 38 (14–88) | 19 (43) | 31 (70) |
| Cappabianca et al14 | 2002 | 1997–2001 | Endoscopic | 146 | 46.1 (16–74) | 76 (52) | 125 (86) |
| White et al45 | 2004 | 2000–2 | Endoscopic | 50 | 41.1 (NA) | 26 (52) | NA |
| Senior et al40 | 2008 | NA | Endoscopic | 148 | 46 (NA) | 81 (55) | 114 (81)† |
| Netea-Meier et al35 | 2006 | 1998–2004 | Endoscopic | 35 | 41 (14–68) | 25 (71) | 6 (17) |
| Rudnik et al38 | 2005 | 2001–2 | Endoscopic | 63 | 48.3 (11–77) | 34 (54) | 52 (83) |
| Kenan et al29 | 2006 | 1997–2005 | Endoscopic | 78 | 44.7 (11–67) | NA | 67 (86) |
| Jain et al27 | 2007 | NA | Endoscopic | 10 | 40.1 (NA) | 6 (60) | 9 (90) |
| Uren et al43 | 2007 | 2001–5 | Endoscopic | 32 | 53 (25–69) | 12 (38) | 23 (72) |
| Frank et al22 | 2006 | 1998–2004 | Endoscopic | 381 | 48 (7–89) | 227 (60) | 284 (75) |
| Dehdashti et al20 | 2008 | 2004–7 | Endoscopic | 200 | 49.9 (20–78) | 109 (55) | 158 (79) |
| Charalampaki et al16 | 2007 | 2004–5 | Endoscopic | 50 | 56 (28–84) | 30 (60) | 41 (82) |
| Yano et al44 | 2009 | 2001–8 | Endoscopic | 194 | 53 (15–85)* | 120 (62) | NA |
| Zhang et al47 | 2008 | 1998–2005 | Endoscopic | 78 | 45.1 (15–76) | 42 (54) | 67 (86) |
| Campbell et al13 | 2010 | 2005–9 | Endoscopic | 26 | 45.7 (20–69) | 12 (46) | 22 |
| Gondim et al23 | 2010 | 1998–2009 | Endoscopic | 301 | 42 (12–79) | 167 (55) | 248 |
| Hofstetter et al25 | 2010 | 2004–10 | Endoscopic | 24 | 50.7 (22–75) | 11 (46) | 19 |
| Nakao et al34 | 2011 | 2000–8 | Endoscopic | 43 | 55 (31–75) | 20 (46) | 43 |
| Casler et al15 | 2005 | 1996–2003 | Endoscopic | 15 | 41.6 | 9 (60) | NA |
| Duz et al21 | 2008 | 1996–2007 | Endoscopic | 28 | NA | NA | NA |
| Choe et al17 | 2008 | 2004–7 | Endoscopic | 12 | 47±12 | 7 (58) | 9 |
| O'Malley et al36 | 2008 | 2003–8 | Endoscopic | 25 | 47.9 (18–73) | 10 (40) | 22 |
| D'Haens et al18 | 2009 | 2001–7 | Endoscopic | 60 | 37 (10–70) | 41 (68) | 31 |
| Messerer et al32 | 2011 | 2006–9 | Endoscopic | 82 | 57 (20–82) | 35 (43) | 82 |
| Jain et al27 | 2007 | NA | Microscopic | 10 | 31.6 (18–58) | 5 (50) | 8 (80) |
| Mortini et al33 | 2005 | 1990–2002 | Microscopic | 1140 | 43 (8–82) | 681 (60) | 788 (69) |
| Höybye et al26 | 2004 | 1990–9 | Microscopic | 34 | 40 (13–74) | 26 (76) | 2 (6) |
| White et al45 | 2004 | 1996–9 | Microscopic | 50 | 43.5 (NA) | 17 (34) | NA |
| Ciric et al1 | 1997 | NA | Microscopic | 638 | NA | NA | NA |
| De et al19 | 2003 | 1980–2001 | Microscopic | 90 | 61 (29–86) | 46 (51) | 61 (68) |
| Rees et al37 | 2002 | 1980–2000 | Microscopic | 54 | 41.3 (14–73) | 42 (78) | 10 (19) |
| Shimon et al42 | 2002 | 1990–2000 | Microscopic | 74 | 39 (8–72) | 64 (86) | 3 (4) |
| Han et al24 | 2008 | 1996–2006 | Microscopic | 592 | 42.3 (NA) | 274 (46) | 592 (100)‡ |
| Kaltsas et al28 | 2001 | 1993–8 | Microscopic | 67 | 46 (12–80)* | 31 (46) | 50 (75) |
| Kreutzer et al31 | 2001 | 1992–8 | Microscopic | 57 | 43.9 (16–71) | 37 (65) | 38 (67) |
| Semple and Laws39 | 1999 | 1992–7 | Microscopic | 105 | 38.5 (6–78) | 83 (79) | 13 (12) |
| Zhang et al46 | 1999 | 1982–97 | Microscopic | 208 | 47.5 (16–71) | 110 (53) | 208 (100) |
| Koren et al30 | 1999 | 1993–5 | Microscopic | 37 | NA | NA | 23 (62) |
| Badie et al12 | 2000 | 1996–9 | Microscopic | 34 | 45.5 (NA) | 17 (50) | 21 (62) |
| Sheehan et al41 | 1999 | 1995–7 | Microscopic | 70 | 58.5 (25–85) | 21 (30) | 70 (100) |
| Casler et al15 | 2005 | 1996–2003 | Microscopic | 15 | 50.6 | 10 (67) | NA |
| Choe et al17 | 2008 | 1997–2004 | Microscopic | 11 | 48±10 | 9 (82) | 8 |
| O'Malley et al36 | 2008 | 2003–8 | Microscopic | 25 | 50.8 (23–78) | 10 (40) | 23 |
| Duz et al21 | 2008 | 1996–2007 | Microscopic | 65 | NA | NA | NA |
| D'Haens et al18 | 2009 | 2001–7 | Microscopic | 60 | 35 (10–68) | 16 (27) | 27 |
| Messerer et al32 | 2011 | 2005 | Microscopic | 82 | 56.5 (27–84) | 35 (43) | 82 |
*Median age.
†Adenoma size was only available in 140 of 148 patients.
‡Including 438 macro and 154 giant.