Table 2

Univariable (unadjusted) ordinal logistic regression analysis showing predictors of increased basal ganglia and centrum semiovale EPVS severity in the whole cohort

Basal ganglia EPVSCentrum semiovale EPVS
(Yes vs No)OR (95% CI)p ValueOR (95% CI)p Value
Age (per 10 years older)1.41 (1.02 to 1.95)0.0361.36 (0.98 to 1.87)0.065
Sex, male0.53 (0.26 to 1.10)0.0880.56 (0.27 to 1.18)0.128
History of hypertension1.05 (0.57 to 2.33)0.4690.68 (0.28 to 1.63)0.381
Smoking history2.89 (1.35 to 6.18)0.0061.20 (0.53 to 2.71)0.666
Diabetes1.26 (050 to 3.16)0.6221.11 (0.39 to 3.13)0.851
On statins0.71 (0.29 to 1.72)0.4410.74 (0.31 to 1.81)0.514
On antithrombotics0.62 (0.28 to 1.38)0.2400.70 (0.31 to 1.57)0.387
First ever ICH0.64 (0.30 to 1.37)0.2481.07 (0.47 to 2.46)0.866
Other ICH (non-CAA aetiology)3.58 (1.70 to 7.54)0.0010.74 (0.35 to 1.57)0.431
Lacunar infarct2.75 (0.93 to 8.14)0.0682.84 (0.87 to 9.29)0.083
Multiple ICHs0.71 (0.34 to 1.47)0.3500.87 (0.41 to 1.86)0.724
Microbleeds presence2.29 (1.01 to 5.21)0.0481.62 (0.73 to 3.56)0.233
Strictly lobar microbleeds0.99 (0.48 to 2.04)0.9851.59 (0.73 to 3.47)0.246
Lobar microbleeds1.81 (0.82 to 3.99)0.1401.89 (0.87 to 4.13)0.109
Deep microbleeds2.25 (1.01 to 4.98)0.0460.97 (0.41 to 2.26)0.937
Mean total white-matter changes score (for each unit increase)1.23 (1.13 to 1.33)<0.00011.01 (0.94 to 1.08)0.772
  • CAA, cerebral amyloid angiopathy; EPVS, enlarged perivascular spaces; ICH, intracerebral haemorrhage.