Table 1

The differential diagnosis of primary progressive multiple sclerosis

Primary progressive MSDifferential diagnosis
Degenerative
 MNDInfective/Inflammatory
 Structural (c. spine/Chiari) HIV
Hereditary Syphilis
 HSP—SCAs Prions
 Leukodystrophies (AMN, Krabbe's), PKU Vasculitis, sarcoid, lupus
Metabolic Schistosomiasis, Brucellosis
 Vitamins B12, ENeoplastic (paraneoplasia)
 CopperIdiopathic/cryptic
 Hypothyroidism
 Toxic—phenytoin, lathyrism, nitric oxide
 Alcohol
  • AMN, adrenomyeloneuropathy; HSP, hereditary spastic paraplegia; MND, motor neuron disease; NO, nitric oxide; PKU, phenylketonuria; SCA, spinocerebellar ataxia.