Table 4

Significant predictors for the Multiple Sclerosis Severity Scale score at 10 years, using the linear regression model

 Whole group (n=261)Relapse onset MS (n=184)Minimally impaired relapse onset MS, EDSS baseline=0–3.5 (n=111)Moderately impaired relapse onset MS, EDSS baseline=4–6 (n=55)CIS (n=18)RRMS (n=97)SPMS (n=69)PPMS (n=77)
b (95% CI)R2 of the model†R2 changeb (95% CI)R2 of the model†R2 changeb (95% CI)R2 of the model†R2 changeb (95% CI)R2 of the modelR2 changeb (95% CI)R2 of the modelR2 changeb (95% CI)R2 of the model‡R2 changeb (95% CI)R2 of the model§R2 changeb (95% CI)R2 of the model§R2 change
Base model0.62** (0.59)0.64** (0.6)0.60** (0.52)0.49** (0.41)0.14* (0.13)0.15** (0.14)
Base model+WBA rate−0.39 (−0.62 to −0.16)0.64** (0.61)0.02*−0.5 (−0.87 to −0.13)0.63** (0.55)0.03*−0.45 (−0.81 to −0.09)0.22** (0.2)0.06*
Base model+CBA rate0.06 (0.01 to 0.11)0.63** (0.60)0.01*0.06 (0.001 to 0.12)0.65** (0.61)0.01*0.1 (0.03 to 0.16)0.63** (0.56)0.03*0.33 (−0.004 to 0.66)0.3 (0.24)0.3 (p=0.052)
Base model+T2LV baseline0.04 (0.007 to 0.07)0.1* (0.09)0.1*
Base model+1 year T2LV0.03 (0.005 to 0.06)0.1* (0.08)0.1*0.03 (0.003 to 0.06)0.52** (0.44)0.03*
Base model+T2LV change/year0.04 (0.01 to 0.08)0.63** (0.6)0.01*0.04 (0.005 to 0.08)0.65** (0.61)0.01*0.04 (0.002 to 0.08)0.51** (0.44)0.03*
  • The columns represent the results for the: whole group, relapse onset patients, minimally impaired and moderately impaired patients, CIS, RRMS, SPMS and PPMS patients. The CIS, RRMS, SPMS and PPMS groups include all patients regardless of their baseline EDSS value. Values are reported as regression coefficients (95% CI within brackets), R2 of the model (adjusted R2 within brackets) and R2 change compared with the base model. The models were compared based on the squared multiple correlation coefficient (R2), R2 change and the general linear test performed using SPSS.

  • *Significant at p<0.05.

  • **Significant at p<0.001.

  • †Base model for the whole group, relapse onset group and minimally impaired group includes imaging protocol, disease type and EDSS baseline.

  • ‡Base model for the RRMS group includes imaging protocol and EDSS baseline.

  • §Base model for the SPMS and PPMS groups includes EDSS baseline.

  • b, (unstandardised) regression coefficient; CBA rate, central brain atrophy rate (percentage ventricular volume change/year); CIS, clinically isolated syndrome; EDSS, Expanded Disability Status Scale; MS, multiple sclerosis; NBV, normalised brain volume; PPMS, primary progressive MS; R2, squared multiple correlation coefficient; RRMS, relapsing remitting MS; SPMS, secondary progressive MS; T2LV, T2 lesion volumes; WBA rate, whole brain atrophy rate (percentage brain volume change/year).