Characteristics | Overall(N=99) | PIGD(N=39) | TD(N=60) |
---|---|---|---|
Age, years | 67.3 (8.5) | 67.0 (10.1) | 67.5 (8.5) |
Male:female, n | 64:35 | 25:14 | 39:21 |
Disease duration, years | 2.3 (1.9) | 2.1 (1.4) | 2.4 (2.2) |
UPDRS ADL score | 8.3 (4.4) | 9.6 (4.7)* | 7.4 (4.0) |
UPDRS motor score | 21.6 (10.6) | 23.0 (11.8) | 20.6 (9.7) |
Tremor score† | 0.59 (0.47) | 0.28 (0.34)** | 0.79 (0.45) |
PIGD score‡ | 0.43 (0.35) | 0.68 (0.38)** | 0.28 (0.23) |
HY stage | 2.0 (0.5) | 2.0 (1.0) | 2.0 (0.5) |
WMH (ml) | 6.7 (12.1) | 4.3 (6.2) | 8.3 (14.8) |
MMSE score | 27.7 (2.6) | 27.7 (2.3) | 27.8 (2.7) |
Attention-executive z-score | –0.35 (0.75) | –0.43 (0.74) | –0.30 (0.77) |
Memory z-score (n=96) | –0.23 (0.80) | –0.27 (0.68) | –0.21 (0.88) |
Visuospatial z-score | –0.14 (0.99) | –0.14 (1.09) | –0.14 (0.93) |
Values denote means (SD) except for male:female ratio (numbers) and HY stage (median/IQR). p Values for continuous variables computed using t tests. Mann–Whitney test for HY stage; χ2 tests for male:female ratio. Cognitive z-scores are corrected for age, sex and education.
*p=0.015; **p<0.001.
†Means of UPDRS items 15, 20 and 21; ‡means of UPDRS items 13–15, 29–30.
ADL, activities of daily living; HY, Hoehn and Yahr stage; MMSE, Mini-Mental State Examination; PIGD, postural instability/gait difficulties; UPDRS, Unified Parkinson's Disease Rating Scale; WMH, white matter hyperintensities.