Table 1

Demographic characteristics of the cohorts

 CharacteristicsPatients with ALS (n=33)Healthy controls (n=44)Patients with bulbar onset (n=13)Patients with limb onset (n=20)
Gender (male:female)18:1524:204:914:6
Age at MRI scan60.79 (13.46)60.21 (9.66)63.24 (6.98)59.20 (16.37)
Handedness (right:left)30:341:311:219:1
Education (1-primary 2-secondary 3-higher)2.15 (0.66)2.18 (0.69)1.93 (0.64)2.3 (0.65)
Disease duration (months) From onset of symptoms to scan29.78 (23.91)N/A21.59 (7.28)35.11 (29.22)
Age at onset of symptoms58.31 (13.95)N/A61.44 (6.93)56.27 (16.92)
Total ALSFRS35.75 (7.04)N/A36.53 (5.85)35.25 (7.82)
ALSFRS bulbar score8.66 (3.13)N/A5.53 (2.25)10.7 (1.52)
ALSFRS respiratory score10.87 (1.31)N/A10.46 (1.61)11.15 (1.0)
Upper Limb score8.45 (3.62)N/A10.69 (1.54)7 (3.86)
  • Values are given in mean (SD) format where appropriate.

  • ALSFRS, Amyotrophic Lateral Sclerosis Functional Rating Scale, range of total ALSFRS: 0–48; range of bulbar scores 0–12, range of respiratory scores 0–12, range of upper limb scores 0–12.