Table 1

Mean (SE) demographic and clinical profiles of autopsy-confirmed and genetic surrogate patients with FTLD-TDP and FTLD-TAU

Group*GroupN (Female)AgeEducationDurationMMSE
FTLD-TDPTotal25 (13)61.6 (1.4)14.8 (0.7)2.9 (0.5)23.0 (1.3)
Autopsy6 (2)58.5 (2.4)16.7 (1.9)2.7 (1.0)23.0 (2.0)
C9ORF7212 (5)61.3 (1.6)14.9 (0.7)3.5 (1.0)25.8 (1.0)
GRN7 (6)64.7 (3.3)13.1 (1.6)2.1 (0.3)17.2 (3.5)†
FTLD-TAUTotal10 (6)62.2 (5.3)15.4 (0.9)2.8 (0.5)20.7 (3.3)
Autopsy7 (4)67.1 (6.2)15.4 (0.9)3.2 (0.6)19.2 (4.3)†
MAPT3 (2)50.7 (7.5)15.3 (2.4)1.7 (0.9)23.7 (5.4)
  • *T tests confirmed that FTLD-TDP and FTLD-TAU were matched for age at MRI (t(33)<1; p>0.1), education (t(33)<1; p>0.1), disease duration (t(33)<1; p>0.1) and disease severity measure using the Mini Mental State Examination (MMSE) (t(31)<1; p>0.1. A χ2 analysis demonstrated that groups were matched for gender (χ2=0.18; p>0.1).

  • †MMSE was not available for one patient from each group.

  • FTLD, frontotemporal lobar degeneration.