Linear regression analysis within the groups where several radiological predictors were statistically significant
| Whole group (n=261) | Relapse onset MS (n=184) | Minimally impaired relapse onset MS, EDSS baseline=0–3.5 (n=111) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EDSS R2 of the model=0.74** (adjusted R2=0.71) | MSSS R2 of the model=0.64** (adjusted R2=0.61) | EDSS R2 of the model=0.72** (adjusted R2=0.69) | MSSS R2 of the model=0.66** (adjusted R2=0.62) | EDSS R2 of the model=0.68** (adjusted R2=0.63) | MSSS R2 of the model=0.63** (adjusted R2=0.56) | |||||||
| b (95% CI) | R2 change | b (95% CI) | R2 change | b (95% CI) | R2 change | b (95% CI) | R2 change | b (95% CI) | R2 change | b (95% CI) | R2 change | |
| Imaging protocol | 0.71** | 0.62** | 0.70** | 0.64** | 0.66** | 0.59** | ||||||
| Use of DMT | −0.79 (−1.45 to −0.13) | −0.86 (−1.6 to −0.12) | −1.32 (−2.28 to −0.4) | |||||||||
| Disease type | ||||||||||||
| Baseline EDSS | 0.8 (0.66 to 0.94) | 0.76 (0.59 to 0.92) | 0.86 (0.7 to 1.02) | 0.84 (0.63 to 1.06) | 0.9 (0.56 to 1.24) | 0.89 (0.4 to 1.37) | ||||||
| WBA rate | −0.39 (−0.62 to −0.16) | 0.02* | ||||||||||
| CBA rate | 0.07 (0.03 to 0.11) | 0.03* | 0.06 (0.01 to 0.1) | 0.02* | 0.07 (0.01 to 0.12) | 0.02* | 0.07 (0.02 to 0.13) | 0.02* | 0.1 (0.03 to 0.16) | 0.04* | ||
| T2LV change/year | 0.04 (0.005 to 0.06) | 0.03 (0 to 0.06) | 0.05 (0.01 to 0.08) | |||||||||
The columns represent the results for the: whole group, relapse onset and minimally impaired patients, Values are reported as R2 of the model (adjusted R2 within brackets), regression coefficients (95% CI within brackets) and R2 change. The models were compared based on the squared multiple correlation coefficient (R2) and the R2 change and with the general linear test performed using SPSS. The normal Q-Q plots of the residuals for all models in the table are depicted in the online supplementary figure.
*Significant at p<0.05.
**Significant at p<0.001.
b, (unstandardised) regression coefficient; CBA rate, central brain atrophy rate (percentage ventricular volume change/year); DMT, disease modifying treatment; EDSS, Expanded Disability Status Scale; MS, multiple sclerosis; MSSS, Multiple Sclerosis Severity Score; R2, squared multiple correlation coefficient; T2LV, T2 lesion volumes WBA rate, whole brain atrophy rate (percentage brain volume change/year).