Table 3

Age at onset in patients with PD according to COMT Val158Met genotype

Met/MetVal/MetVal/ValUnivariate p valueMultivariate p value
Total58.3±13.557.4±13.957.1±13.90.0410.026*
Men57.9±13.657.1±13.656.0±14.10.0130.007**
Women58.8±13.357.7±14.358.6±13.40.290.81**
  • *Multivariate model including cohorts and gender as cofactors.

  • **Multivariate model including cohorts as cofactor.

  • Val/Val: homozygous for the Val158 allele; Val/Met: heterozygous; Met/Met: homozygous for the Met158 allele.

  • COMT, catechol-O-methyltranferase; PD, Parkinson's disease.