Blepharospasm and Meige syndrome
| Reference | Age at surgery (years), mean (range) | Disease duration (years), mean (range) | Surgery | Stimulation parameters (R/L), mean (range) | % Improvement at lastF/U (range) | F/U |
|---|---|---|---|---|---|---|
| Limotai et al41 n=6 | 56.3 (26–68) | 11.3 (5–19) | GPi bilat | 2.52 V (1.8–3.2)/2.75 V (1.5–3.5) 282 μs (60–450)/265 μs (60–450) 140 Hz (10–185)/127 Hz (10–185) | BFM (mov) 61.8% (16.6–100%) Blepharospasm improved in all patients No improvement in speech and swallowing | 12 months |
| Reese et al52 n=12 | 64.5 (57–72) | 8.6 (4–18) | GPi bilat | 3.8 V (2.4–5.0)/3.7 V (2.2–5.0) 143 μs (60–210)/145 μs (90–210) 170 Hz (130–235) | BFM (mov) FU1/FU2 45%/53% Subscores Eyes 38%/47% Mouth 50%/56% Speech 44%/64% | FU1 4.4±1.5 months FU2 38±21.7 months |
| Sako et al53 n=5 | 65 (54–72) | 12 (7–18) | GPi bilat | 2.6 V (1.0–3.9)/2.5 V (1.0–3.6) 392 μs (210–450) 84 Hz (60–130) | BFM (mov) 84% (75–94%) BFM (dis) 89% (80–100%) | 49±43.7 months |
| Tai et al40 n=1 | 66 | 3 | GPi bilat | 2.2–3.2 V/2.2–3.2 V 450 μs 60 Hz | BFM (mov) 75% *continuous mode until 24 months cycling mode 34–60 months | 60 months |
| Ghang et al50 n=11 | 58.3 (45–70) | 8.7 (1–20) | GPi bilat | 3.4 V (2.6–5.0) 133.6 μs (60–210) 143.1 Hz (60–185) | BFM (mov) at 12 months 74.5% Subscores Eyes 63.3% Mouth 80.9% Speech 68.4% Neck 87.9% BFM (mov) at 24 months (n=5) 85.5% | 23.1±6.4 months |
| Lyons et al47 n=3 | 73 63 56 | N/A N/A N/A | GPi bilat GPi bilat GPi bilat | 2.4 V/2.8 V 90 μs 145 Hz 3.6 V/3.0 V 120/60 μs 60/90 Hz 3.0 V/3.0 V 120 μs 130 Hz | BFM (mov) 82% 50% 79% | 54 months 42 months 48 months |
| Markaki et al48 n=1 | 49 | 7 | GPi bilat | 2.6 V/2.6 V 210 μs 185 Hz | BFM (mov) 70% BFM (dis) 93% | 6 months |
| Inoue et al54 n=1 | 61 | 18 | GPi bilat | 3.9 V/3.6 V 450 μs 60 Hz | BFM (mov) 86% BFM (dis) 83% | 10 years |
| Romito et al49 n=1 | 68 | 12 | GPi bilat | 1.3 V/1.3 V 90/90 μs 130/130 Hz | BFM (mov) Subscores Eyes 100% Mouth 100% Speech 100% TWSTRS 93% | 38 months |
| Blomstedt et al55 n=1 | 45 | 19 | GPi bilat | 5.2 V/4.9 V 120 μs 145 Hz | BFM (mov) 71.5% | 18 months |
| Ostrem et al45 n=6 | 62 (52–70) | 8.2 (2–20) | GPi bilat | 3.8 V (3.2–5.0)/3.65 V (2.9–5.0) 205 μs (180–210)/190 μs (90–210) 172 Hz (145–185) | BFM (mov) 72%Subscores Eyes 78.5% Mouth 73.3% Speech 48% TWSTRS 54% | 6 months |
| Opherk et al56 n=1 | 65 | N/A | GPi bilat | N/A | N/A | 4 months |
| Houser and Waltz44 n=1 | 46 | 2 | GPi bilat | 3.8 V/2.6 V 210 μs 160 Hz | BFM (mov) 75% UDRS 85% | 6 months |
| Foote et al42 n=1 | 47 | 5 | GPi bilat | 2.5 V/3.3 V 450 μs 185 Hz | UDRS Eyes 57% Lower face 83% | 15 months |
| Capelle et al57 n=1 | 60 | 5 | 4.3 V/4.3 V 210 μs 130 Hz | BFM (mov) Subscores Eyes 92% Mouth 75% Speech 33% | 24 months | |
| Vercueil et al58 n=1 | 59 | 15 | GPi bilat | N/A | BFM (mov) 66% | 6 months |
| Muta et al59 n=1 | 61 | 18 | GPi bilat | 3.6 V/3.6 V 500 μs 60 Hz | BFM (mov) 80% | N/A |
BFM, Burke–Fahn–Marsden Dystonia rating scale; bilat, bilateral; dis, disability subscore; F/U, follow-up; GPi, internal globus pallidus; L, left; mov, movement subscore; n, number of individuals in each study; N/A, not available; pre-op, preoperative state; post-op, postoperative state; R, right; rest, rest subscore; TWSTRS, Toronto Western Spasmodic Torticollis rating scale.