TableĀ 1

Multivariate Cox regression analyses for the primary endpoint and each activity of daily living milestone using the MRC score of each muscle group at registration

Primary endpointLoss of speechLoss of swallowing functionLoss of upper limb functionDifficulty turning in bedLoss of walking ability
Muscle groupHR (95% CI)p ValueHR (95% CI)p ValueHR (95% CI)p ValueHR (95% CI)p ValueHR (95% CI)p ValueHR (95% CI)p Value
Neck flexors0.74 (0.65to 0.86)<0.0010.66 (0.56 to 0.76)<0.0010.73 (0.63 to 0.85)<0.0010.77 (0.66 to 0.89)0.0010.77 (0.66 to 0.91)0.0020.80 (0.67 to 0.94)0.008
Left shoulder abductors0.87 (0.69 to 1.11)0.2660.89 (0.69 to 1.14)0.3630.89 (0.71 to 1.12)0.3090.62 (0.49 to 0.79)<0.0010.72 (0.56 to 0.93)0.0120.75 (0.57 to 1.00)0.049
Right shoulder abductors0.98 (0.77 to 1.25)0.8901.11 (0.87 to 1.43)0.3991.02 (0.81 to 1.29)0.8671.19 (0.94 to 1.50)0.1591.08 (0.85 to 1.39)0.5290.99 (0.75 to 1.30)0.917
Left wrist extensors1.29 (1.04 to 1.59)0.0181.28 (1.03 to 1.59)0.0261.24 (1.02 to 1.51)0.0341.42 (1.14 to 1.77)0.0021.24 (1.00 to 1.55)0.0541.39 (1.08 to 1.79)0.010
Right wrist extensors0.90 (0.74 to 1.08)0.2540.88 (0.73 to 1.07)0.1930.92 (0.77 to 1.11)0.3800.73 (0.60 to 0.88)0.0010.80 (0.66 to 0.98)0.0290.98 (0.79 to 1.22)0.884
Left hip flexors0.99 (0.72 to 1.36)0.9640.96 (0.73 to 1.28)0.7910.85 (0.62 to 1.15)0.2840.74 (0.55 to 0.99)0.0400.77 (0.56 to 1.06)0.1150.90 (0.61 to 1.32)0.585
Right hip flexors0.96 (0.69 to 1.34)0.8300.95 (0.70 to 1.28)0.7191.09 (0.79 to 1.50)0.6131.18 (0.87 to 1.62)0.2901.18 (0.84 to 1.66)0.3311.06 (0.69 to 1.64)0.788
Left ankle extensors1.14 (0.93 to 1.40)0.2141.13 (0.94 to 1.34)0.1851.14 (0.95 to 1.37)0.1661.26 (1.04 to 1.52)0.0211.09 (0.91 to 1.30)0.3670.93 (0.71 to 1.21)0.583
Right ankle extensors0.94 (0.76 to 1.15)0.5300.95 (0.79 to 1.14)0.5640.94 (0.77 to 1.14)0.5390.85 (0.70 to 1.04)0.1250.81 (0.68 to 0.97)0.0230.72 (0.57 to 0.91)0.007