Table 1

Multivariate Cox regression analyses for the primary endpoint and each activity of daily living milestone using the MRC score of each muscle group at registration

	Primary endpoint		Loss of speech		Loss of swallowing function		Loss of upper limb function		Difficulty turning in bed		Loss of walking ability
Muscle group	HR (95% CI)	p Value	HR (95% CI)	p Value	HR (95% CI)	p Value	HR (95% CI)	p Value	HR (95% CI)	p Value	HR (95% CI)	p Value
Neck flexors	0.74 (0.65to 0.86)	<0.001	0.66 (0.56 to 0.76)	<0.001	0.73 (0.63 to 0.85)	<0.001	0.77 (0.66 to 0.89)	0.001	0.77 (0.66 to 0.91)	0.002	0.80 (0.67 to 0.94)	0.008
Left shoulder abductors	0.87 (0.69 to 1.11)	0.266	0.89 (0.69 to 1.14)	0.363	0.89 (0.71 to 1.12)	0.309	0.62 (0.49 to 0.79)	<0.001	0.72 (0.56 to 0.93)	0.012	0.75 (0.57 to 1.00)	0.049
Right shoulder abductors	0.98 (0.77 to 1.25)	0.890	1.11 (0.87 to 1.43)	0.399	1.02 (0.81 to 1.29)	0.867	1.19 (0.94 to 1.50)	0.159	1.08 (0.85 to 1.39)	0.529	0.99 (0.75 to 1.30)	0.917
Left wrist extensors	1.29 (1.04 to 1.59)	0.018	1.28 (1.03 to 1.59)	0.026	1.24 (1.02 to 1.51)	0.034	1.42 (1.14 to 1.77)	0.002	1.24 (1.00 to 1.55)	0.054	1.39 (1.08 to 1.79)	0.010
Right wrist extensors	0.90 (0.74 to 1.08)	0.254	0.88 (0.73 to 1.07)	0.193	0.92 (0.77 to 1.11)	0.380	0.73 (0.60 to 0.88)	0.001	0.80 (0.66 to 0.98)	0.029	0.98 (0.79 to 1.22)	0.884
Left hip flexors	0.99 (0.72 to 1.36)	0.964	0.96 (0.73 to 1.28)	0.791	0.85 (0.62 to 1.15)	0.284	0.74 (0.55 to 0.99)	0.040	0.77 (0.56 to 1.06)	0.115	0.90 (0.61 to 1.32)	0.585
Right hip flexors	0.96 (0.69 to 1.34)	0.830	0.95 (0.70 to 1.28)	0.719	1.09 (0.79 to 1.50)	0.613	1.18 (0.87 to 1.62)	0.290	1.18 (0.84 to 1.66)	0.331	1.06 (0.69 to 1.64)	0.788
Left ankle extensors	1.14 (0.93 to 1.40)	0.214	1.13 (0.94 to 1.34)	0.185	1.14 (0.95 to 1.37)	0.166	1.26 (1.04 to 1.52)	0.021	1.09 (0.91 to 1.30)	0.367	0.93 (0.71 to 1.21)	0.583
Right ankle extensors	0.94 (0.76 to 1.15)	0.530	0.95 (0.79 to 1.14)	0.564	0.94 (0.77 to 1.14)	0.539	0.85 (0.70 to 1.04)	0.125	0.81 (0.68 to 0.97)	0.023	0.72 (0.57 to 0.91)	0.007