Table 2

Study characteristics and outcome

Article characteristicsSymptom outcomeDisability/functioning
Author (year)SymptomNFollow-up durationFollow-up rate (%)Mean ageDesign% FWorse (%)Same (%)Improved (%)Complete remission (%)Disability %Work %
McKeon (2009)22Tremor623.2 years5350oR70643640% severe, 24% moderate, 36% mild
Jankovic (2006)*14Tremor2113.4 years6044bR734357
Kim (1999)17Tremor701.5 years1441bR663060100
Deuschl (1998)23Tremor250.5–8 years6442bP80253837If symptoms remained: 75% mod and 25% severely impaired daily44% retired
Carter (1949)16Tremor104–6 years80?050050
Schrag (2004)13**Fixed dystonia1033.3 years6730bP+R8373198all on allowance
Ibrahim (2009)12**Fixed dystonia417.6 years7343bP833146230
Lang (1995)24Dystonia18?4435,5oR720373825
Lang (1995)18Parkinsonism14?10043oR500797147% moderate, 57% heavy, 36% fully disabled79% unable to work, 14% early retired, 7% unemployed
Munhoz (2011)25Mixed mov dis830.5 years7039oP88402238
Ertan (2009)26Mixed mov dis4915d–2 years537–70oP7046
Thomas (2006)15*Mixed mov dis5173.4 years2443bR73222157033% employed, 30% on disability, 4% unemployed
Feinstein (2001)27Mixed mov dis883.2 years4845bR623324331017% at work, 76% unemployed
Williams (1995)32Mixed mov dis241.8 years8836,5 onsetR7914572927% disabled27% at work
Factor (1995)21Mixed mov dis280–6 years7151uR6050050
Stone (2003)19Weakness6012.5 years7036bR81693138% limited in moderate activities30% disability leave
Binzer (1998)34Weakness353.5 years8639oP6010276357% at work
Knutsson (1985)28Weakness250.5–9 years10019–47uR7605644
Brown (1954)33Weakness111–6 years9126b?1010202050
Carter (1949)16Weakness234–6 years96?414478
Crimlisk (1998)20Mixed motor735–7 years8837bR483814202833% at work, 47% health related retirement
Mace (1996)29***Mixed motor319.8 years?R784456
Couprie (1995)30Mixed motor604.5 years (median)9336b (median)R6443164134% small restrictions in lifestyle to severely impaired independence, 7% total dependence
Gatfield (1962)31Mixed motor372.5–10 years6514–67bP836238
Ljungberg (1957)35Mixed motor38111.9 years?28,5oP650208065% at work, 14% health related pension
  • Symptom Weakness, functional paralysis/paresis; mixed mov dis, more than one type of movement disorder; mixed motor, mixture of hyperkinetic and movement disorder and weakness/paralysis. Age: bmean age at baseline, omean age at onset of symptoms, uUnclear. %F= percentage females, symptom outcome in percentages. *overlapping studies, **overlapping studies, *** mixed study of sensory and motor symptoms, follow-up rate and total amount of patients with motor symptoms in follow-up unclear.

  • d, days; N, number of patients at baseline; P, prospective; R, retrospective.