Table 2

Study characteristics and outcome

Article characteristics								Symptom outcome				Disability/functioning
Author (year)	Symptom	N	Follow-up duration	Follow-up rate (%)	Mean age	Design	% F	Worse (%)	Same (%)	Improved (%)	Complete remission (%)	Disability %	Work %
McKeon (2009)22	Tremor	62	3.2 years	53	50^o	R	70	64		36		40% severe, 24% moderate, 36% mild	–
Jankovic (2006)*14	Tremor	211	3.4 years	60	44^b	R	73	43		57	–	–	–
Kim (1999)17	Tremor	70	1.5 years	14	41^b	R	66	30	60	10	0	–	–
Deuschl (1998)23	Tremor	25	0.5–8 years	64	42^b	P	80	25	38	–	37	If symptoms remained: 75% mod and 25% severely impaired daily	44% retired
Carter (1949)16	Tremor	10	4–6 years	80	–	?	–	0	50	0	50	–	–
Schrag (2004)13**	Fixed dystonia	103	3.3 years	67	30^b	P+R	83	73		19	8	all on allowance
Ibrahim (2009)12**	Fixed dystonia	41	7.6 years	73	43^b	P	83	31	46	23	0		–
Lang (1995)24	Dystonia	18	?	44	35,5^o	R	72	0	37	38	25
Lang (1995)18	Parkinsonism	14	?	100	43^o	R	50	0	79	7	14	7% moderate, 57% heavy, 36% fully disabled	79% unable to work, 14% early retired, 7% unemployed
Munhoz (2011)25	Mixed mov dis	83	0.5 years	70	39^o	P	88	40		22	38	–	–
Ertan (2009)26	Mixed mov dis	49	15d–2 years	53	7–70^o	P	70	–	–	46	–	–	–
Thomas (2006)15*	Mixed mov dis	517	3.4 years	24	43^b	R	73	22	21	57	0		33% employed, 30% on disability, 4% unemployed
Feinstein (2001)27	Mixed mov dis	88	3.2 years	48	45^b	R	62	33	24	33	10	–	17% at work, 76% unemployed
Williams (1995)32	Mixed mov dis	24	1.8 years	88	36,5 onset	R	79	14		57	29	27% disabled	27% at work
Factor (1995)21	Mixed mov dis	28	0–6 years	71	51^u	R	60	50		0	50	–	–
Stone (2003)19	Weakness	60	12.5 years	70	36^b	R	81	69		31		38% limited in moderate activities	30% disability leave
Binzer (1998)34	Weakness	35	3.5 years	86	39^o	P	60	10		27	63	–	57% at work
Knutsson (1985)28	Weakness	25	0.5–9 years	100	19–47^u	R	76	0	56	44		–	–
Brown (1954)33	Weakness	11	1–6 years	91	26^b	?	10	10	20	20	50
Carter (1949)16	Weakness	23	4–6 years	96	–	?	–	4	14	4	78
Crimlisk (1998)20	Mixed motor	73	5–7 years	88	37^b	R	48	38	14	20	28	–	33% at work, 47% health related retirement
Mace (1996)29***	Mixed motor	31	9.8 years	?		R	78	44		56
Couprie (1995)30	Mixed motor	60	4.5 years (median)	93	36^b (median)	R	64	43		16	41	34% small restrictions in lifestyle to severely impaired independence, 7% total dependence
Gatfield (1962)31	Mixed motor	37	2.5–10 years	65	14–67^b	P	83	62		–	38
Ljungberg (1957)35	Mixed motor	381	11.9 years	?	28,5^o	P	65	0	20	80			65% at work, 14% health related pension

Symptom Weakness, functional paralysis/paresis; mixed mov dis, more than one type of movement disorder; mixed motor, mixture of hyperkinetic and movement disorder and weakness/paralysis. Age: ^bmean age at baseline, ^omean age at onset of symptoms, ^uUnclear. %F= percentage females, symptom outcome in percentages. *overlapping studies, **overlapping studies, *** mixed study of sensory and motor symptoms, follow-up rate and total amount of patients with motor symptoms in follow-up unclear.
d, days; N, number of patients at baseline; P, prospective; R, retrospective.