Table 2

MRI characteristics of the patients

Whole groupRelapse onset MSMinimally impaired relapse onset MS, EDSS baseline=0–3.5Moderately impaired relapse onset MS, EDSS baseline=4–6CISRRMSSPMSPPMS
No of patients2611841115518976977
NBV baseline (l)*1.37 (1.3–1.43)1.37 (1.3–1.43)1.38 (1.35–1.45)1.31 (1.27–1.41)1.43 (1.39–1.46)1.38 (1.33–1.43)1.33 (1.29–1.41)1.36 (1.3–1.42)
WBA rate*−0.69 (−1.17 to –0.19)−0.69 (−1.17 to –0.19)−0.61 (−1.15 to –0.11)−0.74 (−1.22 to –0.25)−0.31 (−0.49 to 0.15)−0.69 (−1.2 to –0.19)−0.81 (−1.2 to –0.23)−0.64 (−1.2 to –0.19)
CBA rate*2.58 (0.42–5.1)2.59 (0.39–4.78)2.6 (0.38–4.41)2.05 (0.13–5.14)0.76 (−0.84–3.02)2.87 (0.81–5.24)1.92 (0.12–4.86)2.47 (0.58–5.69)
T2LV baseline (ml)*5.91 (2.07–13.82)5.89 (1.96–13.68)3.56 (1.45–7.77)10.44 (4.54–19.66)2.28 (1.43–3.92)3.75 (1.44–7.39)12.55 (5.68–23.75)6.25 (2.42–15.7)
1 year T2LV (ml)*9.03 (4.29–19.59)9.23 (4.36–19.71)6.51 (3.9–13.12)14.72 (7.72–26.28)4.56 (3.92–8.36)6.73 (3.63–13.6)14.88 (9.3–27.11)8.62 (3.83–18.78)
T2LV difference per year1.94 (0.59–3.99)1.92 (0.62–3.96)1.76 (0.6–3.6)2.51 (0.85–5.61)2.36 (1.72–3.52)1.88 (0.63–3.97)1.91 (0.2–3.98)1.98 (0.54–4.34)
  • The columns represent the results for the: whole group, relapse onset MS, minimally impaired group (relapse onset patients with baseline EDSS=0–3.5), moderately impaired group (relapse onset patients with baseline EDSS=4–6), CIS, RRMS, SPMS and PPMS patients at baseline. The CIS, RRMS, SPMS and PPMS groups include all patients regardless of their baseline EDSS value.

  • *Data reported as median (IQR).

  • CBA rate, central brain atrophy rate (percentage ventricular volume change/year); CIS, clinically isolated syndrome; EDSS, Expanded Disability Status Scale; MS, multiple sclerosis; NBV, normalised brain volume; PPMS, primary progressive MS; RRMS, relapsing–remitting MS; SPMS, secondary progressive MS; T2LV, T2 lesion volumes; WBA rate, whole brain atrophy rate (percentage brain volume change/year).