Table 1

The significant genotyped SNPs and their associations with 25(OH)D levels and the 25(OH)D-relapse association

Two genotyped SNPs modified the relationship between 25(OH)D and the hazard of relapse
Chr	SNP	bp	Allele	MAF	HR_25(OH)D (95% CI)	P_interact	P_adj_interact	P_relap	P_25(OH)D	Nearest gene
1	rs908742	2033256	A/G	0.283	0.85 (0.77 to 0.94)	0.001	0.021	0.39	0.35	PRKCZ
14	rs3783785	61937292	G/A	0.270	0.83 (0.75 to 0.92)	0.001	0.021	0.14	0.09	PRKCH

Two genotyped SNPs associated with the levels of 25(OH)D (nmol/L)
Chr	SNP	bp	Allele	MAF	Coef_25(OH)D (95% CI)	P_25(OH)D	P_adj_25(OH)D	P_interact	P_relap	Nearest gene
11	rs1993116	14910234	A/G	0.384	−5.14 (−8.27 to −2.01)	0.001	0.021	0.58	0.06	CYP2R1
16	rs7404928	23888840	G/A	0.249	−6.24 (−9.88 to −2.59)	0.001	0.021	0.10	0.95	PRKCB

P_relap: adjusted for age, sex and baseline Expanded Disability Status Scale (EDSS), before adjustment for multiple comparisons.
P_interact: adjusted for age, sex and baseline EDSS, before adjustment for multiple comparisons.
P_25(OH)D: adjusted for sun exposure, season, age, body mass index, vitamin D supplementation, melanin density, fish intake and smoking, before adjustment for multiple comparisons.
p_adj: adjusted for covariates, after adjustment for multiple comparisons for 21 genes involved in the vitamin D metabolism and information complex pathway.
Bp, base pair (hg19); 25(OH)D, 25-hydroxyvitamin D; MAF, minor allele frequency.