Group performance on cognitive domain indices at Assessment 1 (acute phase) and Assessment 2 (post-treatment phase) of VGKC-LE
| Assessment 1 | Assessment 2 | Change between assessments | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Index (z-scores) | n | Mean (SD) | t | N | Mean (SD) | t | n | Mean (SD) | t |
| Verbal memory | 18 | −1.76 (1.02) | −7.47* | 18 | −1.07 (0.96) | −4.54* | 17 | 0.84 (1.05) | 3.30† |
| Non-verbal memory | 17 | −0.52 (1.21) | −2.14 | 19 | 0.23 (0.79) | 1.00 | 17 | 0.76 (1.31) | 2.39 |
| Executive function | 19 | −0.90 (1.00) | −3.92* | 19 | −0.02 (0.72) | −0.09 | 19 | 0.88 (0.76) | 5.03† |
| Processing speed | 17 | −0.76 (0.80) | −3.13* | 16 | −0.10 (1.23) | −0.40 | 16 | 0.69 (1.09) | 2.53 |
| Language | 19 | 0.20 (0.86) | 0.89 | 17 | 0.43 (0.61) | 1.76 | 17 | 0.21 (0.45) | 1.93 |
| Perceptual organisation | 19 | 0.28 (0.49) | 1.22 | 19 | 0.47 (0.47) | 2.06 | 19 | 0.19 (0.44) | 1.92 |
*Impaired (after correction for multiple comparisons, p<0.008).
†Improvement between assessments (after correction for multiple comparisons, p<0.008).
VGKC-LE, limbic encephalitis associated with antibodies to the voltage-gated potassium channel.