Clinical profiles and nerve conduction data of patients with MMN
| Patient nos. | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | |
| Age at onset (year)/sex | 53/M | 36/F | 20/M | 46/M | 57/M | 57/M | 32/F | 51/F | 63/M | 16/M | 16/M |
| Duration (year) | 3 | 5 | 4 | 17 | 1 | 4 | 1 | 10 | 1 | 1 | 2 |
| Site of onset | R/UL | R/UL | R/UL | R/LL | L/UL | L/UL | R/UL | L/UL | L/UL | R/UL | R/UL |
| Currently affected nerves | RL/Med | R/Mus | RL/Uln | L/Mus | L/Mus | L/Med | R/Med | L/Med | L/Med | R/Uln | R/Med |
| RL/Uln | R/Med | R/Rad | L/Uln | RL/Uln | L/Rad | R/Uln | RL/Uln | L/Uln | R/Rad | R/Uln | |
| RL/Rad | R/Uln | R/Per | L/Rad | RL/Rad | R/Rad | R/Rad | L/Rad | ||||
| R/Tib | R/Tib | R/Per | L/Per | ||||||||
| R/Tib | |||||||||||
| Asymmetrically? | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Tendon reflexes in the affected limbs | Absent | Absent | Absent | Decreased | Decreased | Decreased | Normal | Normal | Normal | Normal | Normal |
| Response to IVIg? | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| CSF protein (mg/dL) | 39 | 36 | 21 | 46 | 66 | NA | NA | NA | NA | NA | 42 |
| Positive for serum anti-GM1 IgM antibodies? | No | No | No | Yes | No | Yes | Yes | No | No | No | No |
| Motor conduction study | |||||||||||
| Median nerve | |||||||||||
| Distal latency (ms) | 5.6 | 3.7 | 5.1 | 3.5 | 3.8 | NA | 4.1 | 4.8 | 2.8 | 3.0 | 3.1 |
| CV (m/s) | 64 | 54.6 | 31.6 | 55.0 | 55.9 | NA | 58.0 | 67.0 | 61.0 | 58.0 | 55.0 |
| CMAP amp (mV) (proximal/distal) | 0.2/0.4 | 7.0/9.9 | 0.2/0.5 | 3.8/4.2 | 5.0/5.1 | NA | 1.2/1.2 | 1.2/3.1 | 7.3/7.4 | 7.3/7.5 | 6.8/7.0 |
| CMAP area (mVms) (proximal/distal) | 0.5/0.8 | 23.7/25.0 | 1.1/2.8 | 10.6/10.8 | 15.2/15.8 | NA | 2.6/2.6 | 3.8/10.4 | 21.4/21.5 | 23.9/25.4 | 18.5/20.1 |
| Duration increase (%) (proximal/distal) | 28% | 3% | 22% | 6% | 2% | NA | 3% | 21% | 8% | 4% | 2% |
| F wave lat (ms) | NA | 25.3 | 35.7 | 27.4 | NA | NA | 25.2 | 25.8 | 25.6 | 26.0 | 26.9 |
| Ulnar nerve | |||||||||||
| Distal latency (ms) | 3.3 | 2.5 | 3.2 | 3.5 | 3.0 | 2.9 | 2.1 | 2.5 | 2.9 | 3.3 | 2.8 |
| CV (m/s) | 53.0 | 59.5 | 48.7 | 34.0 | 62.2 | 62.5 | 66.0 | 38.0 | 61.0 | 79.0 | 62.0 |
| CMAP amp (mV) (proximal/distal) | 5.3/5.6 | 5.1/5.2 | 8.7/11.0 | 2.9/4.1 | 4.2/4.4 | 5.6/6.2 | 7.4/7.9 | 1.5/2.2 | 0.6/1.2 | 5.2/5.8 | 4.4/4.4 |
| CMAP area (mVms) (proximal/distal) | 6.1/6.1 | 21.6/25.0 | 17.0/17.0 | 11.1/15.1 | 11.1/11.4 | 19.6/21.8 | 20.8/22.4 | 3.2/5.9 | 13.2/21.4 | 12.1/13.1 | 14.6/15.3 |
| Duration increase (%) (proximal/distal) | 25% | 4% | 0% | 3% | 5% | 29% | 0% | 0% | 13% | 5% | 0% |
| F wave lat (ms) | 29.0 | 23.1 | 33.0 | 28.4 | 29.9 | NA | 23.0 | 28.9 | NA | 27.7 | 27.0 |
| Tibial nerve | |||||||||||
| Distal latency (ms) | 4.6 | 4.6 | 6.6 | 4.9 | 5.2 | NA | NA | 3.5 | NA | NA | NA |
| CV (m/s) | 40 | 47.1 | 28.7 | 47.0 | 43.3 | NA | NA | 44.8 | NA | NA | NA |
| CMAP amp (mV) (proximal/distal) | 2.6/5.5 | 7.9/9.6 | 1.1/2.1 | 1.8/2.4 | 10.2/14.2 | NA | NA | 7.7/10.7 | NA | NA | NA |
| F wave lat (ms) | 56.0 | 40.3 | 84.1 | 54.4 | 51.0 | NA | NA | 40.4 | NA | NA | NA |
| Distribution of CB (definite or probable CB) | Med (probable) | None | Med (probable) | None | None | None | None | Med (probable) | Uln (probable) | None | None |
| Diagnostic categories | Possible | Possible | Possible | Possible | Possible | Possible | Possible | Possible | Possible | Possible | Possible |
CB, conduction block; CMAP amp, compound muscle action potential amplitude; CV, conduction velocity; F wave lat, F wave latency; L, left; LL, lower limb; Med, median nerve; MMN, multifocal motor neuropathy; Mus, musculocutaneus nerve; NA, not available; Per, deep peroneal nerve; R, right; Rad, radial nerve; RL, right and left; Tib, tibial nerve; UL, upper limb; Uln, ulnar nerve.