Outcomes of ventilated TBI patients admitted to the ICU by exposure groups
| Outcomes of patients | Total | Hypoxia | Normoxia | Hyperoxia§ |
|---|---|---|---|---|
| N=1212 | N=553 | N=403 | N=256 | |
| Case fatality (in-hospital), No. (%) | 400 (33) | 224 (40) | 90 (23) | 80 (32)* |
| 95% CI | (30 to 36) | 36 to 44 | (19 to 27) | 26 to 38 |
| Survivors | ||||
| Independent, No. (%) | 205 (17) | 71 (13) | 89 (22) | 51 (20)** |
| 95% CI | (15 to 19) | (10 to 16) | 18 to 26 | 16 to 24 |
| Overall hospital LOS, median (IQR) | 9 (3–17) | 7 (2–17) | 10 (4–17) | 6 (2–16)*** |
*p=.013 for comparison between normoxia and hyperoxia; p<.0001 for comparison between hypoxia and normoxia; and p=0.03 for comparison between hypoxia and hyperoxia.
**p=0.6 for comparison between normoxia and hyperoxia; p= .01 between hypoxia and hyperoxia; and p= .0003 for comparison between hypoxia and normoxia.
***p=0.006 Wilcoxon-Kruskal-Wallis test, all pairs significantly different except for hyperoxia vs. normoxia (Wilcoxon method).
§Defined as arterial PaO2≥300 mm Hg (39.99 kPa).
ICU, intensive care unit; LOS, length of stay; TBI, traumatic brain injury.