Results from preoperative and postoperative examinations and comparisons across assessments and across groups. iNPHDelayed (n=33) waited for surgery for more than 6 months and therefore had two preoperative examinations (Pre-op 1 and Pre-op 2), whereas iNPHEarly (n=69) had shunt surgery within 3 months following the initial assessment (Pre-op 1)
| iNPHDelayed | iNPHEarly | Post-op group comparison | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Pre-op 1 | Pre-op 2 | Post-op | p* | p† | p‡ | Pre-op 1 | Post-op | p§ | p¶ | |
| Total iNPH score | 45 (7–94) | 37 (5–95) | 55 (4–100) | <0.001 | 0.32 | <0.01 | 49 (2–95) | 67 (14–100) | <0.001 | <0.05 |
| Gait | 23 (0–95) | 20 (0–100) | 36 (0–100) | <0.01 | 0.11 | <0.05 | 39 (0–100) | 71 (10–100) | <0.001 | <0.01 |
| Neuropsychology | 40 (5–100) | 28 (0–98) | 40 (2.5–100) | <0.01 | 0.81 | 0.09 | 49 (3–100) | 60 (2.5–100) | <0.001 | <0.05 |
| Balance | 67 (0–100) | 50 (0–100) | 67 (0–100) | <0.01 | 0.79 | <0.01 | 67 (0–100) | 67 (0–100) | <0.001 | <0.05 |
| Continence | 60 (20–100) | 40 (0–100) | 60 (0–100) | 0.068 | 0.84 | 0.61 | 60 (0–100) | 80 (20–100) | <0.001 | 0.18 |
| mRS | 2 (1–4) | 3 (1–5) | 3 (0–5) | <0.001 | 0.82 | <0.05 | 2 (1–4) | 1 (0–5) | <0.001 | <0.01 |
| MMSE | 25 (14–30) | 22 (9–30) | 25 (13–30) | <0.01 | 0.92 | <0.01 | 25 (9–30) | 27 (16–30) | <0.001 | 0.09 |
All data are presented as medians and range.
*Comparison between Pre-op 1 and Pre-op 2 in iNPHDelayed.
†Comparison between Pre-op 1 and Post-op in iNPHDelayed.
‡Comparison between Pre-op 2 and Post-op in iNPHDelayed.
§Comparison between Pre-op 1 and Post-op in iNPHEarly.
¶Comparison between Post-op results for iNPHDelayed and iNPHEarly.
iNPH, idiopathic normal pressure hydrocephalus; MMSE, Mini-Mental State Examination, mRS, modified Rankin Scale.