Table 4

ROC analysis data comparing population diagnostic usefulness of frataxin measurements in whole blood by dipstick assay versus measurements in DBS by Luminex assay

CTL vs CR/FRDACTL/CR vs FRDA
ROC (whole blood, dipstick)
 Sensitivity0.9100.711
 Specificity0.7650.986
 False positive rate0.2350.014
 False negative rate0.0900.289
 Positive predictive value0.9700.985
 Negative predictive value0.5000.729
ROC (whole blood, Luminex)
 Sensitivity0.9630.879
 Specificity0.9570.778
 False positive rate0.0430.222
 False negative rate0.0370.121
 Positive predictive value0.9950.849
 Negative predictive value0.7330.819
  • CR, carrier; CTL, control; FRDA, Friedreich ataxia; ROC, receiver operating characteristic.