Comparisons of [18F]FP-CIT binding potentials among the three groups and between the PD ICD and the PD non-ICD groups
| Regions of comparison | PD ICD | PD non-ICD | Healthy controls | p Value* | p -Value† |
|---|---|---|---|---|---|
| Binding potential values | |||||
| Putamen (PUT) | |||||
| Left | 1.07±0.49 (0.65–2.20) | 1.18±0.37 (0.74–1.93) | 2.93±0.40 (2.38–3.73) | <0.001 | 1.000 |
| Right | 0.94±0.20 (0.52–1.20) | 1.26±0.46 (0.71–1.94) | 2.89±0.45 (2.43–3.76) | <0.001 | 0.162 |
| Caudate nucleus (CAU) | |||||
| Left | 1.21±0.57 (0.40–2.29) | 1.55±0.74 (0.46–2.85) | 2.44±0.46 (1.91–3.33) | <0.001 | 0.634 |
| Right | 1.08±0.46 (0.28–1.79) | 1.42±0.76 (0.55–2.75) | 2.40±0.43 (2.01–3.30) | <0.001 | 0.551 |
| Nucleus accumbens (NAC) | |||||
| Left | 1.32±0.57 (0.21–2.62) | 2.04±0.84 (0.88–3.60) | 1.58±0.47 (1.04–2.65) | 0.050 | 0.049 |
| Right | 1.33±0.68 (0.28–3.11) | 1.76±0.68 (0.77–0.76) | 1.42±0.39 (0.91–2.28) | 0.243 | 0.331 |
| Amygdala (AMG) | |||||
| Left | 0.31±0.11 (0.01–0.39) | 0.39±0.13 (0.25–0.66) | 0.39±0.09 (0.29–0.54) | 0.160 | 0.329 |
| Right | 0.31±0.10 (0.05–0.41) | 0.36±0.13 (0.22–0.64) | 0.39±0.10 (0.25–0.55) | 0.276 | 0.754 |
| Orbitofrontal cortex (OFC) | |||||
| Left | 0.20±0.12 (0.01–0.38) | 0.17±0.07 (0.06–0.31) | 0.19±0.07 (0.07–0.32) | 0.702 | 1.000 |
| Right | 0.18±0.12 (0.02–0.36) | 0.17±0.07 (0.05–0.31) | 0.18±0.07 (0.08–0.32) | 0.965 | 1.000 |
| Ventromedial prefrontal cortex (VMPFC) | |||||
| Left | 0.33±0.09 (0.20–0.45) | 0.30±0.07 (0.17–0.41) | 0.15±0.08 (0.02–0.29) | <0.001 | 1.000 |
| Right | 0.33±0.09 (0.22–0.47) | 0.24±0.07 (0.11–0.35) | 0.17±0.08 (0.04–0.31) | 0.001 | 0.033 |
Data are shown as mean±SD.
*Comparison among the three groups by the analysis of variance.
†Comparison between PD-ICD and PD non-ICD groups by post hoc analysis.
p Values are adjusted values and are significant if they are <0.05.
ICD, impulse control disorder; PD, Parkinson's disease.