Table 1

Patient characteristics

Multiple sclerosis (n=35)Other ADS (n=47)p Value
Age at onset
 Mean, SD14.7±2.87.5±4.8p<0.001
Type of onset (%)  p<0.001
 Optic neuritis6 (17.1%)10 (21.3%)
 Transverse myelitis1 (2.9%)2 (4.3%)
Other monofocal CIS12 (34.3%)2 (4.3%)
Polyfocal CIS16 (45.7%)13 (27.7%)
ADEM20 (42.6%)
CSF analysis performed (%)31 (88.6%)45 (95.7%)NS
Positive CSF (valid %)*26 (83.9%)8 (17.8%)p<0.001
Follow-up time, months (mean, SD)32±1738±12NS
Final diagnosis according to the 2007 and 2012 consensus definitionsCDMS30CIS22
Definite MS based on5ADEM19
MRI evidence NMO4
Other relapsing ADS2
  • *CSF positivity is defined by either the presence of oligloclonal bands or an elevated IgG index.10

  • ADEM, acute disseminated encephalomyelitis; ADS, acquired demyelinating syndromes; CDMS, clinical definite multiple sclerosis; CIS, clinically isolated syndrome; CSF, cerebrospinal fluid; MS, multiple sclerosis; NMO, neuromyelitis optica; NS, non-significant.