Areas of significantly (p<0.05 and corrected for multiple comparisons in each voxel) reduced GM perfusion measurements in early RRMS patients relative to controls
| Anatomical regions | Cluster size | MNI coordinates (mm) | t Values |
|---|---|---|---|
| Intracalcarine cortex | 33 816 | 26, −60, 7 | 5.42 |
| Right thalamus | 15, −15, 18 | 4.44 | |
| Parahippocampal gyrus, anterior division | −32, −19, −24 | 4.36 | |
| Left hippocampus | −32, −19, −24 | 4.36 | |
| Temporal fusiform cortex, posterior division | −34.5, −19.5, −25.5 | 4.18 | |
| Lingual gyrus | 21, −60, 4.5 | 4.07 | |
| Precuneous cortex | 7.5, −60, 43.5 | 3.69 | |
| Right caudate | 18, −15, 22.55 | 3.44 | |
| Right putamen | 19.5, 16.5, −3 | 2.83 | |
| Left thalamus | −4.5, −15, 13.5 | 2.79 | |
| Angular gyrus | 1097 | −39, −55, 16 | 3.17 |
| Lateral occipital cortex, superior division | −23, −78, 24 | 3.03 | |
| Occipital pole | 777 | −36, −91.5, −16.5 | 4.25 |
| Lateral occipital cortex, inferior division | −36, −91.5, −9 | 3.33 | |
| Inferior temporal gyrus, posterior division | 738 | 63, −18, −28.5 | 2.94 |
| Middle temporal gyrus | 61.5, −18, −31.5 | 2.88 | |
| Superior parietal lobule | 568 | −24, −49, 46 | 3.4 |
| Postcentral gyrus | −22.5, −43.5, 54 | 3.01 | |
| Central opercular cortex | 444 | 42, −6, 15 | 3.19 |
| Insular cortex | 42, −6, 9 | 3.10 | |
| Superior temporal gyrus, posterior division | 402 | −52.5, −37.5, 4.5 | 2.70 |
| Frontal operculum cortex | 325 | 35, 26, 9 | 3.05 |
| Parietal operculum cortex | 217 | −51, −31, 22 | 2.93 |
| Frontal pole | 144 | 5, 66, −8 | 3.02 |
| Frontal orbital cortex | 85 | −27, 33, −9 | 2.92 |
| Inferior frontal gyrus, pars opercularis | 80 | −33, 20, 24 | 3.23 |
| Middle frontal gyrus | −36, 19.5, 28.5 | 2.88 |
GM, grey matter; MNI, Montreal Neurological Institute; RRMS, relapsing-remitting multiple sclerosis.