Table 2

Predictors of postpartum relapses

Crude HR (95% CI; p value)Adjusted HR (95% CI; p value) in time-dependent analysis*
EDSS at conception ≥2.01.7 (1.2 to 2.3; 0.003)1.4 (1.1 to 2.0; 0.046)
Relapses in the year prior to pregnancy1.6 (1.3 to 1.9; <0.001)1.5 (1.2 to 1.8; <0.001)
Relapses during pregnancy2.5 (1.7 to 3.6; <0.001)2.3 (1.6 to 3.4; <0.001)
Early DMDs after delivery0.5 (0.3 to 0.8; 0.007)0.7 (0.4 to 1.0; 0.079)
  • Variables included in the model: current age, disease duration and EDSS at conception (<2.0 vs ≥2.0), DMDs before pregnancy, number of relapses in the year before pregnancy and during pregnancy, smoking, alcohol and toxin exposure during pregnancy (yes vs no), breast feeding (yes vs no) and DMD introduction after delivery (early vs delayed).

  • *In the time-dependent analysis, the early DMD value is 0 until drug introduction and changes to 1 thereafter. For delayed DMD, the value remains 0 in the follow-up.

  • DMDs, disease modifying drugs; EDSS, Expanded Disability Status Scale.