Demographic and clinical characteristics of 10 Huntington's disease patients who underwent human fetal striatal transplantation
| ID | Sex | Onset age in years (calendar year) | Years of education | CAG repeats | Affected parent | Symptom at onset | DB | Drugs (mg/day) | Age in years, at grafting |
|---|---|---|---|---|---|---|---|---|---|
| 1 | F | 34 (1999) | 8 | 49 | Mother | Motor | 459 | PMZ (6); STR (50); DZM (2.5); TBZ (37.5) | 40 |
| 2+ | M | 44 (1995) | 8 | 44 | Father | Motor | 374 | PMZ (6); STR (25); DZM (2); TBZ (12.5); VPA (900) | 55 |
| 3+ | M | 44 (1994) | 10 | 48 | Unknown | Motor | 550 | STR (200); DZM (5) | 56 |
| 4 | M | 21 (1996) | 8 | 60 | Mother | Motor | 514 | PMZ (8); TBZ (62.5) | 34 |
| 5 | M | 28 (1993) | 12 | 48 | Father | Motor | 350 | TBZ (37.5); VPA (300) | 42 |
| 6 | F | 33 (1990) | 10 | 42 | Father | Psychiatric | 214 | PMZ (6); STR (50); DZM (4); TBZ (62.5) | 52 |
| 7+ | M | 32 (2000) | 8 | 56 | Mother | Motor | 656 | TPR (100) | 39 |
| 8 | M | 48 (2003) | 18 | 47 | Mother | Cognitive | 552 | PMZ (6); STR (25); DZM (2.5); TBZ (25) | 54 |
| 9 | M | 46 (2002) | 8 | 43 | Mother | Motor | 345 | STR (150); TBZ (50); AMD (100) | 52 |
| 10 | M | 48 (1999) | 8 | 44 | Mother | Psychiatric | 408 | STR (50); DZM (2.5); TBZ (37.5) | 57 |
+, patient who died; AMD, amantadine; CAG, cytosine-adenine-guanine; DB, disease burden measured as (CAG number–35.5)×age-at-onset23; DZM, diazepam; F, female; ID, patient identifier; M, male; PMZ: pimozide; STR, sertraline; TBZ, tetrabenazine; TPR, tiapride; VPA, sodium valproate.