Table 3

Frequency of individual clinical features in patients with pathological CBD in our patient cohort compared with the data of Armstrong et al1

At presentation n (%)During entire course n (%)
Clinical featurePublishedOur dataPublishedOur data
Limb rigidity65/114 (57)10/17 (59)153/180 (85)13/18 (72)
Bradykinesia/clumsy limb53/111 (48)10/17 (59)126/165 (76)11/18 (61)
Bradykinesia8/16 (50)11/17 (65)
Clumsy limb10/17 (59)10/18 (56)
Postural instability20/49 (41)4/16 (25)73/94 (78)8/17 (47)
Falls27/76 (36)3/14 (21)83/111 (75)8/15 (53)
Abnormal gait30/92 (33)5/17 (29)102/140 (73)13/18 (72)
Axial rigidity18/67 (27)4/15 (27)68/98 (69)5/16 (31)
Tremor17/83 (20)7/15 (47)50/127 (39)8/16 (50)
Limb dystonia18/91 (20)4/17 (24)47/123 (38)6/18 (33)
Myoclonus14/94 (15)2/15 (13)34/128 (28)5/15 (33)
Cognitive impairment (overall)59/114 (52)14/18 (78)123/175 (70)17/19 (89)
Objective cognitive impairment14/18 (78)17/19 (89)
Behavioural changes52/113 (46)9/17 (53)82/150 (55)14/18 (78)
Limb apraxia46/102 (45)11/17 (65)81/142 (57)14/18 (78)
Aphasia40/101 (40)10/19 (53)80/155 (52)11/20 (55)
Depression21/80 (26)3/16 (19)42/82 (51)4/17 (24)
Cortical sensory loss20/81 (25)4/17 (24)29/107 (27)5/18 (28)
Alien limb20/90 (22)5/17 (29)24/81 (30)5/18 (28)
Abnormal eye movement29/88 (33)7/16 (44)90/150 (60)8/16 (50)
Hyperreflexia17/57 (30)6/18 (33)58/116 (50)6/18 (33)
Speech changes18/77 (23)6/15 (40)59/112 (53)7/15 (47)
Abnormal eye movement29/88 (33)7/16 (44)90/150 (60)8/16 (50)
  • Data given for the presence/absence of each clinical feature at presentation and during the entire course of diagnosed disease. The denominator used was the number of patients with documented presence/absence of each clinical feature. The percentage frequencies of individual clinical features in our cohort and that of Armstrong et al1 were strongly correlated: r=0.78 at presentation and r=0.58 during entire course of disease across all variables (Pearson correlation).

  • CBD, corticobasal degeneration.