At presentation n (%) | During entire course n (%) | |||
---|---|---|---|---|
Clinical feature | Published | Our data | Published | Our data |
Limb rigidity | 65/114 (57) | 10/17 (59) | 153/180 (85) | 13/18 (72) |
Bradykinesia/clumsy limb | 53/111 (48) | 10/17 (59) | 126/165 (76) | 11/18 (61) |
Bradykinesia | – | 8/16 (50) | – | 11/17 (65) |
Clumsy limb | – | 10/17 (59) | – | 10/18 (56) |
Postural instability | 20/49 (41) | 4/16 (25) | 73/94 (78) | 8/17 (47) |
Falls | 27/76 (36) | 3/14 (21) | 83/111 (75) | 8/15 (53) |
Abnormal gait | 30/92 (33) | 5/17 (29) | 102/140 (73) | 13/18 (72) |
Axial rigidity | 18/67 (27) | 4/15 (27) | 68/98 (69) | 5/16 (31) |
Tremor | 17/83 (20) | 7/15 (47) | 50/127 (39) | 8/16 (50) |
Limb dystonia | 18/91 (20) | 4/17 (24) | 47/123 (38) | 6/18 (33) |
Myoclonus | 14/94 (15) | 2/15 (13) | 34/128 (28) | 5/15 (33) |
Cognitive impairment (overall) | 59/114 (52) | 14/18 (78) | 123/175 (70) | 17/19 (89) |
Objective cognitive impairment | – | 14/18 (78) | – | 17/19 (89) |
Behavioural changes | 52/113 (46) | 9/17 (53) | 82/150 (55) | 14/18 (78) |
Limb apraxia | 46/102 (45) | 11/17 (65) | 81/142 (57) | 14/18 (78) |
Aphasia | 40/101 (40) | 10/19 (53) | 80/155 (52) | 11/20 (55) |
Depression | 21/80 (26) | 3/16 (19) | 42/82 (51) | 4/17 (24) |
Cortical sensory loss | 20/81 (25) | 4/17 (24) | 29/107 (27) | 5/18 (28) |
Alien limb | 20/90 (22) | 5/17 (29) | 24/81 (30) | 5/18 (28) |
Abnormal eye movement | 29/88 (33) | 7/16 (44) | 90/150 (60) | 8/16 (50) |
Hyperreflexia | 17/57 (30) | 6/18 (33) | 58/116 (50) | 6/18 (33) |
Speech changes | 18/77 (23) | 6/15 (40) | 59/112 (53) | 7/15 (47) |
Abnormal eye movement | 29/88 (33) | 7/16 (44) | 90/150 (60) | 8/16 (50) |
Data given for the presence/absence of each clinical feature at presentation and during the entire course of diagnosed disease. The denominator used was the number of patients with documented presence/absence of each clinical feature. The percentage frequencies of individual clinical features in our cohort and that of Armstrong et al1 were strongly correlated: r=0.78 at presentation and r=0.58 during entire course of disease across all variables (Pearson correlation).
CBD, corticobasal degeneration.