Table 2

ROC analysis data comparing two diagnostic methods from frataxin measurements in whole blood and buccal cells by dipstick assay

CTL vs CR/FRDACTL/CR vs FRDA
ROC (whole blood)
 Sensitivity0.9380.818
 Specificity0.8510.971
 False positive rate0.1490.029
 False negative rate0.0620.182
 Positive predictive value0.9760.976
 Negative predictive value0.6790.794
ROC (buccal cells)
 Sensitivity0.9220.898
 Specificity0.8060.810
 False positive rate0.1940.190
 False negative rate0.0780.102
 Positive predictive value0.9690.813
 Negative predictive value0.6150.897
  • CR, carrier; CTL, control; FRDA, Friedreich ataxia; ROC, receiver operating characteristic.