TableĀ 1

Cumulative outcomes for all pregnancies

Valproate monotherapy exposuresCarbamazepine monotherapy exposuresLamotrigine monotherapy exposures
Number of exposures (informative exposures)1290 (1220)1718 (1657)2198 (2098)
Outcome1214 live births1651 live births2093 live births
49 spontaneous abortions45 spontaneous abortions80 spontaneous abortions
16 stillbirths6 stillbirths15 stillbirths
11 induced abortions15 induced abortions10 induced abortions
1 ectopic pregnancy
Maternal age at delivery, years28.330.428.9
Mean number of previous pregnancies1.11.11.0
Folic acid consumption (preconceptual, %)1159 yes (40.4%)1568 yes (47.9%)1879 yes (53.9%)
111 no128 no137 no
20 unknown22 unknown77 unknown
Positive family history for MCM35 (2.7%)43 (2.5%)66 (3.2%)
Gender557 male814 male1015 male
600 female756 female998 female
133 unknown148 unknown185 unknown
Mean daily dose (mg)906.9631.7256.1
Major malformations824349
Major congenital malformation rate, 95% CI6.7% (5.5% to 8.3%)2.6% (1.9% to 3.5%)2.3% (1.8% to 3.1%)
  • MCM, major congenital malformation.