Clinical impact of human fetal striatal transplantation in Huntington's disease
| Not-grafted HD patients’ series | Total HD patients’ series | Grafted HD patients’ series | |||
|---|---|---|---|---|---|
| Worsening in UHDRS total scores* | Years to worse in absence of grafting† | Years to worse in presence of grafting‡ | Savings (years)§ | Savings (years)§ | |
| Functional | −5 | 7.1 (5.0 to 12.5) | 7.6 (5.2 to 14.7) | 0.5 (−2.6 to 4.2) | 1.6 (−1.1 to 5.9) |
| Behavioural | Not calculable | ||||
| Cognitive | −40 | 3.5 (2.5 to 5.5) | 4.5 (2.9 to 10.2) | 1.0 (0.1 to 12.0) | 1.0 (0.2 to 3.6) |
| Motor | 30 | 5.8 (4.7 to 7.5) | 7.0 (5.3 to 10.0) | 1.2 (0.02 to 2.8) | 2.6 (1.3 to 4.9) |
*Difference between average values at study entry and average values at the end of the study for not-grafted Huntington's Disease (HD) patients (clinically significant worsening: W).
†Number of years needed to reach such difference in not-transplanted HD patients (number of years needed to worse: NNWnt). From the regression analysis results as: NNWnt=W/slope.
‡Number of years needed to reach such difference in presence of grafting (number of years needed to worse: NNWt). From the regression analysis results as: NNWt=W/(slope+change-in-slope).
§Difference NNWt—NNWnt. NNW and savings in years (95% bootstrap CIs).28
UHDRS, Unified Huntington's Disease Rating Scale.